Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes

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Electrophysiological and microfluorometric measurements were combined to analyse the responses of rat striatal medium spiny (MS) and large aspiny (LA) interneurons to the mitochondrial uncoupler carbonyl cyanide p-trifluoromethoxyphenylidrazone (FCCP). FCCP produced a membrane depolarisation coupled to an irreversible increase in intracellular calcium [Ca2+]i in MS. Conversely, LA interneurons hyperpolarised and a moderate [Ca2+]i rise was observed. Cyclosporin A, inhibitor of the mitochondrial membrane transition pore, prevented the FCCP-induced changes in LA interneurons, whereas only a partial reduction was observed in MS cells. The present results indicate that mitochondrial Ca2+ released into the cytosol may contribute to the selective vulnerability to metabolic impairment in striatal neuronal subtypes.

Original languageEnglish
Pages (from-to)641-644
Number of pages4
Issue number5
Publication statusPublished - Apr 16 2002


  • Bis-fura-2
  • Calcium
  • Electrophysiology
  • FCCP
  • Mitochondria
  • Striatal slices

ASJC Scopus subject areas

  • Neuroscience(all)


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