TY - JOUR
T1 - Impact of HIV-1 tropism on the emergence of non-AIDS events in HIV–infected patients receiving fully suppressive antiretroviral therapy
AU - Maffongelli, Gaetano
AU - Alterib, Claudia
AU - Gentilotti, Elisa
AU - Bertoli, Ada
AU - Ricciardi, Alessandra
AU - Malagnino, Vincenzo
AU - Svicher, Valentina
AU - Santoro, Maria M.
AU - Dori, Luca
AU - Perno, Carlo F.
AU - Andreoni, Massimo
AU - Sarmati, Loredana
PY - 2015/11/20
Y1 - 2015/11/20
N2 - OBJECTS: : The impact of HIV-1 tropism on the emergence of non-AIDS events was evaluated in a cohort of 116 antiretroviral (ART) responder patients. METHODS: : The patients were followed for the emergence of hypertension, renal impairment, metabolic and bone disorders (defined as non-AIDS events) each 8 weeks at standard visits. A V3 plasma sequence genotype analysis was performed at the time of ART initiation and the geno2pheno algorithm with the results that defines the false positive rate (FPR) was used to infer HIV tropism. The associations between the non-AIDS events and the FPR at baseline were evaluated using the Chi-squared test for trend. A Cox regression analysis using the counting process formulation of Andersen and Gill was performed to define whether the emergence of non-AIDS events was correlated to FPR. RESULTS: : The prevalence of at least one non-AIDS event resulted higher in patients with a FPR
AB - OBJECTS: : The impact of HIV-1 tropism on the emergence of non-AIDS events was evaluated in a cohort of 116 antiretroviral (ART) responder patients. METHODS: : The patients were followed for the emergence of hypertension, renal impairment, metabolic and bone disorders (defined as non-AIDS events) each 8 weeks at standard visits. A V3 plasma sequence genotype analysis was performed at the time of ART initiation and the geno2pheno algorithm with the results that defines the false positive rate (FPR) was used to infer HIV tropism. The associations between the non-AIDS events and the FPR at baseline were evaluated using the Chi-squared test for trend. A Cox regression analysis using the counting process formulation of Andersen and Gill was performed to define whether the emergence of non-AIDS events was correlated to FPR. RESULTS: : The prevalence of at least one non-AIDS event resulted higher in patients with a FPR
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U2 - 10.1097/QAD.0000000000000977
DO - 10.1097/QAD.0000000000000977
M3 - Article
AN - SCOPUS:84947998268
SN - 0269-9370
JO - AIDS
JF - AIDS
ER -