TY - JOUR
T1 - Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe
T2 - Results of a European concerted action
AU - Bréchot, Christian
AU - Jaffredo, Franck
AU - Lagorce, David
AU - Gerken, Guido
AU - Zum Büschenfelde, Karl Meyer
AU - Papakonstontinou, Anastasia
AU - Hadziyannis, Stephanos
AU - Romeo, Raffaela
AU - Colombo, Massimo
AU - Rodes, Joan
AU - Bruix, Jordi
AU - Williams, Roger
AU - Naoumov, Nikolai
PY - 1998/8
Y1 - 1998/8
N2 - Background/Aims: To investigate the impact of hepatitis B (HBV) and C (HCV) infections on hepatocellular carcinoma (HCC) in Europe. Methods: Five hundred and three patients with HCC, from six liver centers, were included. All 503 sera and 80 liver samples were tested for HBV DNA and HCV RNA by polymerase chain reaction. GBV-C/HGV RNA was also tested in 57 sera. Results: HBsAg and anti-HCV were detected in 19% and 40.1% of the patients, respectively. Serum and liver HBV DNA were detected in 82% and 91% of the HBsAg positive subjects. HBV DNA was also detected in the serum and liver of 33% and 47% of HBsAg negative patients. In this group, serum HBV DNA was more prevalent in anti-HBs and/or anti-HBc patients (47.9%), compared to those without any HBV marker (25.1%). HCV RNA was detected in 89% and 7% of anti- HCV positive and negative cases, respectively, HCV 1b being the most prevalent genotype (80%). Coinfection with HBV and HCV was shown in 20.4% of patients, while only 29% had neither HBV nor HCV. GBV-C/HGV RNA was detected in only 4/57 sera. Conclusions: This study offers the first large analysis of HCC in Europe, based on both serology and molecular tests. It demonstrates the major impact of HBV and HCV, but not of GBV-C/HGV, in liver carcinogenesis in Northern as well as Southern Europe. It also stresses the need to use viral genome detection in epidemiological studies when serological tests are negative.
AB - Background/Aims: To investigate the impact of hepatitis B (HBV) and C (HCV) infections on hepatocellular carcinoma (HCC) in Europe. Methods: Five hundred and three patients with HCC, from six liver centers, were included. All 503 sera and 80 liver samples were tested for HBV DNA and HCV RNA by polymerase chain reaction. GBV-C/HGV RNA was also tested in 57 sera. Results: HBsAg and anti-HCV were detected in 19% and 40.1% of the patients, respectively. Serum and liver HBV DNA were detected in 82% and 91% of the HBsAg positive subjects. HBV DNA was also detected in the serum and liver of 33% and 47% of HBsAg negative patients. In this group, serum HBV DNA was more prevalent in anti-HBs and/or anti-HBc patients (47.9%), compared to those without any HBV marker (25.1%). HCV RNA was detected in 89% and 7% of anti- HCV positive and negative cases, respectively, HCV 1b being the most prevalent genotype (80%). Coinfection with HBV and HCV was shown in 20.4% of patients, while only 29% had neither HBV nor HCV. GBV-C/HGV RNA was detected in only 4/57 sera. Conclusions: This study offers the first large analysis of HCC in Europe, based on both serology and molecular tests. It demonstrates the major impact of HBV and HCV, but not of GBV-C/HGV, in liver carcinogenesis in Northern as well as Southern Europe. It also stresses the need to use viral genome detection in epidemiological studies when serological tests are negative.
KW - HBV
KW - HCC
KW - HCV
KW - HGV
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U2 - 10.1016/S0168-8278(98)80001-9
DO - 10.1016/S0168-8278(98)80001-9
M3 - Article
C2 - 9722197
AN - SCOPUS:0032145740
SN - 0168-8278
VL - 29
SP - 173
EP - 183
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 2
ER -