Impact of child obesity on adipose tissue physiology: Assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity

Maria Chiara Leoni; Chiara Valsecchi; Melissa Mantelli; Laura Marastoni; Carmine Tinelli; Antonietta Marchi; Annamaria Castellazzi

doi:10.4081/pr.2010.e19

Impact of child obesity on adipose tissue physiology: Assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity

Maria Chiara Leoni, Chiara Valsecchi, Melissa Mantelli, Laura Marastoni, Carmine Tinelli, Antonietta Marchi, Annamaria Castellazzi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Pediatric Reports
Volume	2
Issue number	2
DOIs	https://doi.org/10.4081/pr.2010.e19
Publication status	Published - 2010

Keywords

Adipocytokines
BMI z-score
Inflammatory cytokines
Obesity

ASJC Scopus subject areas

Pediatrics

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10.4081/pr.2010.e19

Cite this

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abstract = "Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P",

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T1 - Impact of child obesity on adipose tissue physiology

T2 - Assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity

AU - Leoni, Maria Chiara

AU - Valsecchi, Chiara

AU - Mantelli, Melissa

AU - Marastoni, Laura

AU - Tinelli, Carmine

AU - Marchi, Antonietta

AU - Castellazzi, Annamaria

PY - 2010

Y1 - 2010

N2 - Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P

AB - Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P

KW - Adipocytokines

KW - BMI z-score

KW - Inflammatory cytokines

KW - Obesity

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Impact of child obesity on adipose tissue physiology: Assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity

Abstract

Keywords

ASJC Scopus subject areas

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