Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Catherine Gebhard; Ronny R. Buechel; Barbara E Stähli; Heidi Gransar; Stephan Achenbach; Daniel S. Berman; Matthew J. Budoff; Tracy Q. Callister; Benjamin J W Chow; Allison Dunning; Mouaz H Al-Mallah; Filippo Cademartiri; Kavitha Chinnaiyan; Ronen Rubinshtein; Hugo Marques; Augustin DeLago; Todd C. Villines; Martin Hadamitzky; Joerg Hausleiter; Leslee J. Shaw; Ricardo C. Cury; Gudrun Feuchtner; Yong Jin Kim; Erica Maffei; Gilbert Raff; Gianluca Pontone; Daniele Andreini; Hyuk Jae Chang; Jonathon Leipsic; James K. Min; Philipp A. Kaufmann

doi:10.1093/ehjci/jew142

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Catherine Gebhard, Ronny R. Buechel, Barbara E Stähli, Heidi Gransar, Stephan Achenbach, Daniel S. Berman, Matthew J. Budoff, Tracy Q. Callister, Benjamin J W Chow, Allison Dunning, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Ronen Rubinshtein, Hugo Marques, Augustin DeLago, Todd C. Villines, Martin Hadamitzky, Joerg Hausleiter, Leslee J. ShawRicardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk Jae Chang, Jonathon Leipsic, James K. Min, Philipp A. Kaufmann

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking.

METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001).

CONCLUSION: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.

Original language	English
Journal	European Heart Journal Cardiovascular Imaging
DOIs	https://doi.org/10.1093/ehjci/jew142
Publication status	E-pub ahead of print - Jul 26 2016

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Journal Article

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10.1093/ehjci/jew142

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Gebhard, C., Buechel, R. R., Stähli, B. E., Gransar, H., Achenbach, S., Berman, D. S., Budoff, M. J., Callister, T. Q., Chow, B. J. W., Dunning, A., Al-Mallah, M. H., Cademartiri, F., Chinnaiyan, K., Rubinshtein, R., Marques, H., DeLago, A., Villines, T. C., Hadamitzky, M., Hausleiter, J., ... Kaufmann, P. A. (2016). Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study. European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jew142

Gebhard, C, Buechel, RR, Stähli, BE, Gransar, H, Achenbach, S, Berman, DS, Budoff, MJ, Callister, TQ, Chow, BJW, Dunning, A, Al-Mallah, MH, Cademartiri, F, Chinnaiyan, K, Rubinshtein, R, Marques, H, DeLago, A, Villines, TC, Hadamitzky, M, Hausleiter, J, Shaw, LJ, Cury, RC, Feuchtner, G, Kim, YJ, Maffei, E, Raff, G, Pontone, G , Andreini, D, Chang, HJ, Leipsic, J, Min, JK & Kaufmann, PA 2016, 'Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study', European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jew142

@article{7df883900b1f4374a9b0559c5a6bedaf,

title = "Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study",

abstract = "BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking.METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001).CONCLUSION: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.",

keywords = "Journal Article",

author = "Catherine Gebhard and Buechel, {Ronny R.} and St{\"a}hli, {Barbara E} and Heidi Gransar and Stephan Achenbach and Berman, {Daniel S.} and Budoff, {Matthew J.} and Callister, {Tracy Q.} and Chow, {Benjamin J W} and Allison Dunning and Al-Mallah, {Mouaz H} and Filippo Cademartiri and Kavitha Chinnaiyan and Ronen Rubinshtein and Hugo Marques and Augustin DeLago and Villines, {Todd C.} and Martin Hadamitzky and Joerg Hausleiter and Shaw, {Leslee J.} and Cury, {Ricardo C.} and Gudrun Feuchtner and Kim, {Yong Jin} and Erica Maffei and Gilbert Raff and Gianluca Pontone and Daniele Andreini and Chang, {Hyuk Jae} and Jonathon Leipsic and Min, {James K.} and Kaufmann, {Philipp A.}",

year = "2016",

month = jul,

day = "26",

doi = "10.1093/ehjci/jew142",

language = "English",

journal = "European Heart Journal Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography

T2 - results from the prospective multicentre CONFIRM study

AU - Gebhard, Catherine

AU - Buechel, Ronny R.

AU - Stähli, Barbara E

AU - Gransar, Heidi

AU - Achenbach, Stephan

AU - Berman, Daniel S.

AU - Budoff, Matthew J.

AU - Callister, Tracy Q.

AU - Chow, Benjamin J W

AU - Dunning, Allison

AU - Al-Mallah, Mouaz H

AU - Cademartiri, Filippo

AU - Chinnaiyan, Kavitha

AU - Rubinshtein, Ronen

AU - Marques, Hugo

AU - DeLago, Augustin

AU - Villines, Todd C.

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Shaw, Leslee J.

AU - Cury, Ricardo C.

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Maffei, Erica

AU - Raff, Gilbert

AU - Pontone, Gianluca

AU - Andreini, Daniele

AU - Chang, Hyuk Jae

AU - Leipsic, Jonathon

AU - Min, James K.

AU - Kaufmann, Philipp A.

PY - 2016/7/26

Y1 - 2016/7/26

N2 - BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking.METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001).CONCLUSION: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.

AB - BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking.METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001).CONCLUSION: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.

KW - Journal Article

U2 - 10.1093/ehjci/jew142

DO - 10.1093/ehjci/jew142

M3 - Article

C2 - 27461207

SN - 2047-2404

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

ER -

Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

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