TY - JOUR
T1 - Immunotherapy-related imaging findings in patients with gynecological malignancies
T2 - What radiologists need to know
AU - Russo, Luca
AU - Avesani, Giacomo
AU - Gui, Benedetta
AU - Trombadori, Charlotte Marguerite Lucille
AU - Salutari, Vanda
AU - Perri, Maria Teresa
AU - Di Paola, Valerio
AU - Rodolfino, Elena
AU - Scambia, Giovanni
AU - Manfredi, Riccardo
N1 - Publisher Copyright:
© 2021 The Korean Society of Radiology.
PY - 2021/8
Y1 - 2021/8
N2 - Immunotherapy is an effective treatment option for gynecological malignancies. Radiologists dealing with gynecological patients undergoing treatment with immune checkpoint inhibitors should be aware of unconventional immune-related imaging features for the evaluation of tumor response and immune-related adverse events. In this paper, immune checkpoint inhibitors used for gynecological malignancies and their mechanisms of action are briefly presented. In the second part, patterns of pseudoprogression are illustrated, and different forms of immune-related adverse events are discussed.
AB - Immunotherapy is an effective treatment option for gynecological malignancies. Radiologists dealing with gynecological patients undergoing treatment with immune checkpoint inhibitors should be aware of unconventional immune-related imaging features for the evaluation of tumor response and immune-related adverse events. In this paper, immune checkpoint inhibitors used for gynecological malignancies and their mechanisms of action are briefly presented. In the second part, patterns of pseudoprogression are illustrated, and different forms of immune-related adverse events are discussed.
KW - Adverse drug event
KW - Checkpoint inhibitors
KW - Gynaecological oncology
KW - Pseudoprogression
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UR - http://www.scopus.com/inward/citedby.url?scp=85112589556&partnerID=8YFLogxK
U2 - 10.3348/kjr.2020.1299
DO - 10.3348/kjr.2020.1299
M3 - Review article
C2 - 34047505
AN - SCOPUS:85112589556
SN - 1229-6929
VL - 22
SP - 1310
EP - 1322
JO - Korean Journal of Radiology
JF - Korean Journal of Radiology
IS - 8
ER -