Immunological status in heroin addicts: Effects of methadone maintenance treatment

A. Lazzarin; L. Mella; M. Trombini; C. Uberti-Foppa; F. Franzetti; G. Mazzoni; M. Galli

doi:10.1016/0376-8716(84)90051-6

Immunological status in heroin addicts: Effects of methadone maintenance treatment

A. Lazzarin, L. Mella, M. Trombini, C. Uberti-Foppa, F. Franzetti, G. Mazzoni, M. Galli

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In opiate addicts specific and unspecific immune responses were examined, before and after methadone treatment. Anomalous immune responses were characterized by compromised cellular immunity (functional deficits of polymorphonuclear leukocytes and T-lymphocytes) in association with efficient production of antibodies. After methadone treatment an elevation of leukocyte functions was noted. The presence of elevated titres of circulating immune complexes observed in all the patients tested could bring about a functional exhaustion of neutrophils. The defects of cellular immunity can be considered important risk factors in the pathogenesis of infectious diseases in addicts.

Original language	English
Pages (from-to)	117-123
Number of pages	7
Journal	Drug and Alcohol Dependence
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0376-8716(84)90051-6
Publication status	Published - 1984

Keywords

Heroin-addicts
Humoral immunity
Methadone treatment
Polymorphonuclear leukocytes
T-lymphocytes

ASJC Scopus subject areas

Medicine(all)
Behavioral Neuroscience
Toxicology
Health(social science)

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10.1016/0376-8716(84)90051-6

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title = "Immunological status in heroin addicts: Effects of methadone maintenance treatment",

abstract = "In opiate addicts specific and unspecific immune responses were examined, before and after methadone treatment. Anomalous immune responses were characterized by compromised cellular immunity (functional deficits of polymorphonuclear leukocytes and T-lymphocytes) in association with efficient production of antibodies. After methadone treatment an elevation of leukocyte functions was noted. The presence of elevated titres of circulating immune complexes observed in all the patients tested could bring about a functional exhaustion of neutrophils. The defects of cellular immunity can be considered important risk factors in the pathogenesis of infectious diseases in addicts.",

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author = "A. Lazzarin and L. Mella and M. Trombini and C. Uberti-Foppa and F. Franzetti and G. Mazzoni and M. Galli",

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TY - JOUR

T1 - Immunological status in heroin addicts

T2 - Effects of methadone maintenance treatment

AU - Lazzarin, A.

AU - Mella, L.

AU - Trombini, M.

AU - Uberti-Foppa, C.

AU - Franzetti, F.

AU - Mazzoni, G.

AU - Galli, M.

PY - 1984

Y1 - 1984

N2 - In opiate addicts specific and unspecific immune responses were examined, before and after methadone treatment. Anomalous immune responses were characterized by compromised cellular immunity (functional deficits of polymorphonuclear leukocytes and T-lymphocytes) in association with efficient production of antibodies. After methadone treatment an elevation of leukocyte functions was noted. The presence of elevated titres of circulating immune complexes observed in all the patients tested could bring about a functional exhaustion of neutrophils. The defects of cellular immunity can be considered important risk factors in the pathogenesis of infectious diseases in addicts.

AB - In opiate addicts specific and unspecific immune responses were examined, before and after methadone treatment. Anomalous immune responses were characterized by compromised cellular immunity (functional deficits of polymorphonuclear leukocytes and T-lymphocytes) in association with efficient production of antibodies. After methadone treatment an elevation of leukocyte functions was noted. The presence of elevated titres of circulating immune complexes observed in all the patients tested could bring about a functional exhaustion of neutrophils. The defects of cellular immunity can be considered important risk factors in the pathogenesis of infectious diseases in addicts.

KW - Heroin-addicts

KW - Humoral immunity

KW - Methadone treatment

KW - Polymorphonuclear leukocytes

KW - T-lymphocytes

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JO - Drug and Alcohol Dependence

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Immunological status in heroin addicts: Effects of methadone maintenance treatment

Abstract

Keywords

ASJC Scopus subject areas

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