TY - JOUR
T1 - Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature
AU - Santandrea, Giacomo
AU - Piana, Simonetta
AU - Valli, Riccardo
AU - Zanelli, Magda
AU - Gasparini, Elisa
AU - de Leo, Antonio
AU - Mandato, Vincenzo Dario
AU - Palicelli, Andrea
N1 - Publisher Copyright:
© 2021 by the authors.
PY - 2021/1
Y1 - 2021/1
N2 - The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.
AB - The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.
KW - Biomarkers
KW - Immunohistochemistry
KW - Molecular classification
KW - Ovarian cancer
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U2 - 10.3390/diagnostics11020199
DO - 10.3390/diagnostics11020199
M3 - Review article
AN - SCOPUS:85100594511
SN - 2075-4418
VL - 11
JO - Diagnostics
JF - Diagnostics
IS - 2
M1 - 199
ER -