TY - JOUR
T1 - Immunoglobulin e levels in the 1st year of life
AU - De Amici, Mara
AU - Belloni, Cesare
AU - De Silvestri, Annalisa
AU - Perotti, Francesca
AU - Quaglini, Silvana
AU - Ciprandi, Giorgio
AU - Marseglia, Gianluigi
PY - 2008/1
Y1 - 2008/1
N2 - Asthma allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. The correlation between maternal and fetal immunoglobulin E (IgE) seems to be caused by genetic factors rather than placental transfer. The purpose of this study was to evaluate and quantify the relationship of IgE levels between mothers and their offspring during the 1st year of life. Total serum IgE levels were assessed in 104 healthy pregnant women just before delivery, as well as in 104 newborns in the 1st days of life and then again at 3, 5, 6, 11 and 12 months of age. A serum IgE increase in infants during the 1st year of life is related to maternal serum IgE levels (and may be divided into three classes, according to IgE concentrations of 100, and 100 kU/L exceeded the norm during the 1st year of life, in the absence of overt atopic disease. It seems useful to consider different categories of infants, as a function of their mothers' IgE, to plan a particular follow-up for children in higher risk classes.
AB - Asthma allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. The correlation between maternal and fetal immunoglobulin E (IgE) seems to be caused by genetic factors rather than placental transfer. The purpose of this study was to evaluate and quantify the relationship of IgE levels between mothers and their offspring during the 1st year of life. Total serum IgE levels were assessed in 104 healthy pregnant women just before delivery, as well as in 104 newborns in the 1st days of life and then again at 3, 5, 6, 11 and 12 months of age. A serum IgE increase in infants during the 1st year of life is related to maternal serum IgE levels (and may be divided into three classes, according to IgE concentrations of 100, and 100 kU/L exceeded the norm during the 1st year of life, in the absence of overt atopic disease. It seems useful to consider different categories of infants, as a function of their mothers' IgE, to plan a particular follow-up for children in higher risk classes.
KW - Atopy
KW - Cohort
KW - Infancy
KW - Pregnancy
KW - Prevention
KW - Risk factors
KW - Risks of allergy
KW - Serial measurements
KW - Serum IgE
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U2 - 10.2500/aap2008.29.3081
DO - 10.2500/aap2008.29.3081
M3 - Article
C2 - 18302842
AN - SCOPUS:40449087668
SN - 1088-5412
VL - 29
SP - 74
EP - 77
JO - Allergy and Asthma Proceedings
JF - Allergy and Asthma Proceedings
IS - 1
ER -