Immune modulation in critically ill septic patients

Salvatore Lucio Cutuli; Simone Carelli; Domenico Luca Grieco; Gennaro De Pascale

doi:10.3390/medicina57060552

Immune modulation in critically ill septic patients

Salvatore Lucio Cutuli, Simone Carelli, Domenico Luca Grieco, Gennaro De Pascale

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients.

Original language	English
Article number	552
Journal	Medicina (Lithuania)
Volume	57
Issue number	6
DOIs	https://doi.org/10.3390/medicina57060552
Publication status	Published - Jun 2021

Keywords

Blood purification
Extracorporeal immune modulation
Infection
Renal replacement therapy
Sepsis
Septic shock

ASJC Scopus subject areas

Medicine(all)

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10.3390/medicina57060552

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title = "Immune modulation in critically ill septic patients",

abstract = "Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients.",

keywords = "Blood purification, Extracorporeal immune modulation, Infection, Renal replacement therapy, Sepsis, Septic shock",

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AU - Cutuli, Salvatore Lucio

AU - Carelli, Simone

AU - Grieco, Domenico Luca

AU - De Pascale, Gennaro

PY - 2021/6

Y1 - 2021/6

N2 - Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients.

AB - Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients.

KW - Blood purification

KW - Extracorporeal immune modulation

KW - Infection

KW - Renal replacement therapy

KW - Sepsis

KW - Septic shock

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Immune modulation in critically ill septic patients

Abstract

Keywords

ASJC Scopus subject areas

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