IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

S. Malhotra; C. Morcillo-Suárez; D. Brassat; R. Goertsches; J. Lechner-Scott; E. Urcelay; O. Fernández; J. Drulovic; A. García-Merino; F. Martinelli Boneschi; A. Chan; K. Vandenbroeck; A. Navarro; M. F. Bustamante; J. Río; D. A. Akkad; G. Giacalone; A. J. Sánchez; L. Leyva; R. Alvarez-Lafuente; U. K. Zettl; J. Oksenberg; X. Montalban; M. Comabella

doi:10.1016/j.jneuroim.2011.08.004

IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

S. Malhotra, C. Morcillo-Suárez, D. Brassat, R. Goertsches, J. Lechner-Scott, E. Urcelay, O. Fernández, J. Drulovic, A. García-Merino, F. Martinelli Boneschi, A. Chan, K. Vandenbroeck, A. Navarro, M. F. Bustamante, J. Río, D. A. Akkad, G. Giacalone, A. J. Sánchez, L. Leyva, R. Alvarez-LafuenteU. K. Zettl, J. Oksenberg, X. Montalban, M. Comabella

IRCCS Ospedale San Raffaele

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Abstract

Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	239
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.08.004
Publication status	Published - Oct 28 2011

Keywords

Interferon-beta
Multiple sclerosis
Polymorphisms
Response

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/j.jneuroim.2011.08.004

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Malhotra, S., Morcillo-Suárez, C., Brassat, D., Goertsches, R., Lechner-Scott, J., Urcelay, E., Fernández, O., Drulovic, J., García-Merino, A., Martinelli Boneschi, F., Chan, A., Vandenbroeck, K., Navarro, A., Bustamante, M. F., Río, J., Akkad, D. A., Giacalone, G., Sánchez, A. J., Leyva, L., ... Comabella, M. (2011). IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis. Journal of Neuroimmunology, 239(1-2), 101-104. https://doi.org/10.1016/j.jneuroim.2011.08.004

Malhotra, S, Morcillo-Suárez, C, Brassat, D, Goertsches, R, Lechner-Scott, J, Urcelay, E, Fernández, O, Drulovic, J, García-Merino, A, Martinelli Boneschi, F, Chan, A, Vandenbroeck, K, Navarro, A, Bustamante, MF, Río, J, Akkad, DA, Giacalone, G, Sánchez, AJ, Leyva, L, Alvarez-Lafuente, R, Zettl, UK, Oksenberg, J, Montalban, X & Comabella, M 2011, 'IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis', Journal of Neuroimmunology, vol. 239, no. 1-2, pp. 101-104. https://doi.org/10.1016/j.jneuroim.2011.08.004

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abstract = "Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.",

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AU - Lechner-Scott, J.

AU - Urcelay, E.

AU - Fernández, O.

AU - Drulovic, J.

AU - García-Merino, A.

AU - Martinelli Boneschi, F.

AU - Chan, A.

AU - Vandenbroeck, K.

AU - Navarro, A.

AU - Bustamante, M. F.

AU - Río, J.

AU - Akkad, D. A.

AU - Giacalone, G.

AU - Sánchez, A. J.

AU - Leyva, L.

AU - Alvarez-Lafuente, R.

AU - Zettl, U. K.

AU - Oksenberg, J.

AU - Montalban, X.

AU - Comabella, M.

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IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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