Idiopathic recurring stupor

Paolo Tinuper; P. Montagna; G. Plazzi; P. Avoni; A. Cerullo; P. Cortelli; E. Sforza; E. P. Bonetti; P. Schoch; J. D. Rothstein; A. Guidotti; E. Lugaresi

Idiopathic recurring stupor

Paolo Tinuper, P. Montagna, G. Plazzi, P. Avoni, A. Cerullo, P. Cortelli, E. Sforza, E. P. Bonetti, P. Schoch, J. D. Rothstein, A. Guidotti, E. Lugaresi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.

Original language	English
Pages (from-to)	621-625
Number of pages	5
Journal	Neurology
Volume	44
Issue number	4
Publication status	Published - 1994

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
Neuroscience(all)

Cite this

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title = "Idiopathic recurring stupor",

abstract = "Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.",

author = "Paolo Tinuper and P. Montagna and G. Plazzi and P. Avoni and A. Cerullo and P. Cortelli and E. Sforza and Bonetti, {E. P.} and P. Schoch and Rothstein, {J. D.} and A. Guidotti and E. Lugaresi",

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T1 - Idiopathic recurring stupor

AU - Tinuper, Paolo

AU - Montagna, P.

AU - Plazzi, G.

AU - Avoni, P.

AU - Cerullo, A.

AU - Cortelli, P.

AU - Sforza, E.

AU - Bonetti, E. P.

AU - Schoch, P.

AU - Rothstein, J. D.

AU - Guidotti, A.

AU - Lugaresi, E.

PY - 1994

Y1 - 1994

N2 - Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.

AB - Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.

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M3 - Article

C2 - 8164814

AN - SCOPUS:0028198717

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JO - Neurology

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Idiopathic recurring stupor

Abstract

ASJC Scopus subject areas

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