Idiopathic recurring stupor

Paolo Tinuper, P. Montagna, G. Plazzi, P. Avoni, A. Cerullo, P. Cortelli, E. Sforza, E. P. Bonetti, P. Schoch, J. D. Rothstein, A. Guidotti, E. Lugaresi

Research output: Contribution to journalArticlepeer-review


Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS patients in whom there were no metabolic, toxic, or structural brain dysfunctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreactive background activity. Flumazenil, a benzodiazepine receptor antagonist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine-like activity identified as endozepine-4. IRS may be due to an unexplained excess of endozepine-4.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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