Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid

F. Fussi; F. Savoldi; M. Curti

doi:10.1016/0304-3940(87)90518-0

Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid

F. Fussi, F. Savoldi, M. Curti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.

Original language	English
Pages (from-to)	308-310
Number of pages	3
Journal	Neuroscience Letters
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90518-0
Publication status	Published - Jun 26 1987

Keywords

Carboxyethyl γ-aminobutyric acid (CEGABA)
GABA derivative
Polyamine derivative
Putreanine
Spermidine

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(87)90518-0

Cite this

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title = "Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid",

abstract = "The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.",

keywords = "Carboxyethyl γ-aminobutyric acid (CEGABA), GABA derivative, Polyamine derivative, Putreanine, Spermidine",

author = "F. Fussi and F. Savoldi and M. Curti",

year = "1987",

month = jun,

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doi = "10.1016/0304-3940(87)90518-0",

language = "English",

volume = "77",

pages = "308--310",

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T1 - Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid

AU - Fussi, F.

AU - Savoldi, F.

AU - Curti, M.

PY - 1987/6/26

Y1 - 1987/6/26

N2 - The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.

AB - The di-carboxylated derivative of spermidine, N-carboxyethyl γ-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.

KW - Carboxyethyl γ-aminobutyric acid (CEGABA)

KW - GABA derivative

KW - Polyamine derivative

KW - Putreanine

KW - Spermidine

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Identification of N-carboxyethyl γ-aminobutyric acid in bovine brain and human cerebrospinal fluid

Abstract

Keywords

ASJC Scopus subject areas

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