TY - JOUR
T1 - Ictal haemodynamic changes in a patient affected by "subtle" Epilepsia Partialis Continua
AU - Vaudano, Anna Elisabetta
AU - Di Bonaventura, Carlo
AU - Carni, Marco
AU - Rodionov, Roman
AU - Lapenta, Leonardo
AU - Casciato, Sara
AU - Fattouch, Jinane
AU - Egeo, Gabriella
AU - Pantano, Patrizia
AU - Nucciarelli, Valter
AU - Maraviglia, Bruno
AU - Prencipe, Massimiliano
AU - Lemieux, Louis
AU - Giallonardo, Anna Teresa
PY - 2012/1
Y1 - 2012/1
N2 - We report on a 64 year-old woman presenting with Epilepsia Partialis Continua (EPC) affecting the left hand since the age of 24 without neurological deficit. Structural MRI showed a region of focal cortical dysplasia (FCD) over the right central gyrus and lesions in the mesial frontal and occipital cortex secondary to perinatal hypoxic injury. Ictal spike haemodynamic mapping using simultaneous EEG-fMRI revealed significant BOLD signal changes prominent in the region of FCD (larger cluster), occipital cortex (global statistical maximum), prefrontal cortex and cerebellum. The cluster over FCD was in good agreement with the result of EEG source analysis. Our findings provide an interesting illustration of the ability of EEG-fMRI to reveal epileptogenic networks confirming the intrinsic epileptogenic properties of dysplastic neurons.
AB - We report on a 64 year-old woman presenting with Epilepsia Partialis Continua (EPC) affecting the left hand since the age of 24 without neurological deficit. Structural MRI showed a region of focal cortical dysplasia (FCD) over the right central gyrus and lesions in the mesial frontal and occipital cortex secondary to perinatal hypoxic injury. Ictal spike haemodynamic mapping using simultaneous EEG-fMRI revealed significant BOLD signal changes prominent in the region of FCD (larger cluster), occipital cortex (global statistical maximum), prefrontal cortex and cerebellum. The cluster over FCD was in good agreement with the result of EEG source analysis. Our findings provide an interesting illustration of the ability of EEG-fMRI to reveal epileptogenic networks confirming the intrinsic epileptogenic properties of dysplastic neurons.
KW - EEG/fMRI
KW - Epilepsia Partialis Continua
KW - Focal cortical dysplasia
UR - http://www.scopus.com/inward/record.url?scp=84355166662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84355166662&partnerID=8YFLogxK
U2 - 10.1016/j.seizure.2011.09.003
DO - 10.1016/j.seizure.2011.09.003
M3 - Article
C2 - 21958459
AN - SCOPUS:84355166662
SN - 1059-1311
VL - 21
SP - 65
EP - 69
JO - Seizure : the journal of the British Epilepsy Association
JF - Seizure : the journal of the British Epilepsy Association
IS - 1
ER -