Ictal clinical electroencephalographic findings of spasms in West syndrome

L. Fusco, F. Vigevano, P. Genton, A. Portera-Sanchez, C. G. Lipinski

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The electroencephalographic/video recordings of 955 spasms in children with cryptogenic and symptomatic West syndrome (WS) were reviewed to define the relation between a clinical manifestation of a spasm and its EEG pattern, and to examine whether these features reflect the etiology and prognosis of WS. The review confirmed the spasm to be a distinct type of seizure, with a unique clinical and EEG pattern unlike that of all other recognized seizures. Symmetric spasms were present in cryptogenic and symptomatic patients. In contrast, asymmetric spasms, or focal signs recognizable during a spasm, strongly indicated the existence of a cerebral lesion. In both etiological groups, the characteristic ictal EEG pattern of the spasms consisted of a positive-vertex slow wave. The other two patterns apparently correlated to a spasm, were fast activity, here called spindle-like, and decremental activity. The fast activity corresponded to a clinical stare, and the decremental activity, when present, represented a postictal event. Although it was independent from the etiology of the spasms, persisting hypsarrhythmia during a cluster of spasms appeared to be an EEG pattern that correlated with a favorable outcome.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
Issue number4
Publication statusPublished - 1993


  • Child
  • Electroencephalography
  • Hypsarrhythmia
  • Infantile spasms
  • Neurologic manifestations
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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