Hypopituitarism following brain injury: When does it occur and how best to test?

Valentina Gasco, Flavia Prodam, Loredana Pagano, Silvia Grottoli, Sara Belcastro, Paolo Marzullo, Guglielmo Beccuti, Ezio Ghigo, Gianluca Aimaretti

Research output: Contribution to journalArticlepeer-review


Aim of this review is to highlight how and when Traumatic Brain Injury (TBI) as well as Subarachnoid Haemorrhage (SAH) and primary Brain Tumours (pBT) of the Central Nervous System (CNS) can induce hypopituitarism, an under-diagnosed clinical problem. Moreover, this review aims to clarify, on the basis of the recent evidences, how these patients have to be tested for pituitary-function. Both retrospective and prospective studies recommended that patients with more severe form of Brain Injuries (BI) and in particular, those with fractures of the base of the skull or early diabetes insipidus, have to be closely monitored for signs and symptoms of endocrine dysfunction. Further studies will be crucial to raise awareness and remind physicians on the prevalence of hypopituitarism in patients with BI and to elucidate any incremental benefits these patients may receive from hormone replacement.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
Issue number1
Publication statusPublished - Mar 2012


  • Brain Injuries
  • Diagnosis
  • Hypopituitarism

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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