TY - JOUR
T1 - Hypomelanosis of Ito
T2 - Electron microscopical observations on two new cases
AU - Cavallari, V.
AU - Ussia, A. F.
AU - Siragusa, M.
AU - Schepis, C.
PY - 1996/10
Y1 - 1996/10
N2 - An ultrastructural study on two new cases of Ito's hypomelanosis is reported. According with previous studies on this pathological condition, a marked reduction of melanocytes is detected in the hypopigmented areas. In the proximity of preserved melanocytes, a nearly normal content of melanosomes is detected in basal keratinocytes. Melanocyte profiles are frequently located in close relationship with the basal lamina. An apparent increase of nerve endings is demonstrated at the dermo-epidermal edge. Nerve fibres show no pathological alterations. A functional impairment of the melanocytes is hypothesized, involving regressive changes and a tendency towards a round shape of their profiles. This could in part account for the prevalent basal location of the melanocytes. The role of the dermal nerve endings in the pathogenesis of the hypopigmented lesions is discussed.
AB - An ultrastructural study on two new cases of Ito's hypomelanosis is reported. According with previous studies on this pathological condition, a marked reduction of melanocytes is detected in the hypopigmented areas. In the proximity of preserved melanocytes, a nearly normal content of melanosomes is detected in basal keratinocytes. Melanocyte profiles are frequently located in close relationship with the basal lamina. An apparent increase of nerve endings is demonstrated at the dermo-epidermal edge. Nerve fibres show no pathological alterations. A functional impairment of the melanocytes is hypothesized, involving regressive changes and a tendency towards a round shape of their profiles. This could in part account for the prevalent basal location of the melanocytes. The role of the dermal nerve endings in the pathogenesis of the hypopigmented lesions is discussed.
KW - Blaschko's lines
KW - Hypomelanosis of Ito
KW - Ultrastructure
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U2 - 10.1016/0923-1811(95)00507-2
DO - 10.1016/0923-1811(95)00507-2
M3 - Article
C2 - 8902659
AN - SCOPUS:0030271921
SN - 0923-1811
VL - 13
SP - 87
EP - 92
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - 1
ER -