Ipersensibilità agli anticoagulanti orali: Descrizione di un caso

M. M. Patella; P. E. Russo; D. De Lucia; M. Margaglione; D. Colaizzo; A. Iacono

Ipersensibilità agli anticoagulanti orali: Descrizione di un caso

Translated title of the contribution: Hypersensitivity to oral anticoagulants: A case report

M. M. Patella, P. E. Russo, D. De Lucia, M. Margaglione, D. Colaizzo, A. Iacono

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case regarding a 71 year-old Caucasian man with NYHA functional class III congestive heart failure, who was under warfarin treatment due to left ventricular thrombosis. After a few days, although the drug was not overdosed, the INR increased up to 11.68. Normal values were reestablished only after a 20-day pharmacological wash-out. Surprisingly, no episode of major or minor bleeding occurred. Gene typing of cytochrome P450 CYP2C9, a liver enzyme responsible for warfarin metabolism, showed that the patient was a carrier of both the mutant alleles (CYP2C9*2/*3) of this enzyme. This genetic defect caused a reduced catabolism of S-warfarin and excessive anticoagulation.

Translated title of the contribution	Hypersensitivity to oral anticoagulants: A case report
Original language	Italian
Pages (from-to)	303-306
Number of pages	4
Journal	Italian Heart Journal Supplement
Volume	2
Issue number	3
Publication status	Published - 2001

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

@article{407eb5a6c1ed4e3babb9e9c757e044a2,

title = "Ipersensibilit{\`a} agli anticoagulanti orali: Descrizione di un caso",

abstract = "We report a case regarding a 71 year-old Caucasian man with NYHA functional class III congestive heart failure, who was under warfarin treatment due to left ventricular thrombosis. After a few days, although the drug was not overdosed, the INR increased up to 11.68. Normal values were reestablished only after a 20-day pharmacological wash-out. Surprisingly, no episode of major or minor bleeding occurred. Gene typing of cytochrome P450 CYP2C9, a liver enzyme responsible for warfarin metabolism, showed that the patient was a carrier of both the mutant alleles (CYP2C9*2/*3) of this enzyme. This genetic defect caused a reduced catabolism of S-warfarin and excessive anticoagulation.",

keywords = "Anticoagulation, CYP2C9 polymorphism, Warfarin",

author = "Patella, {M. M.} and Russo, {P. E.} and {De Lucia}, D. and M. Margaglione and D. Colaizzo and A. Iacono",

year = "2001",

language = "Italian",

volume = "2",

pages = "303--306",

journal = "Italian Heart Journal Supplement",

issn = "1129-4728",

publisher = "Centro Editoriale Pubblicitario Italiano",

number = "3",

}

TY - JOUR

T1 - Ipersensibilità agli anticoagulanti orali

T2 - Descrizione di un caso

AU - Patella, M. M.

AU - Russo, P. E.

AU - De Lucia, D.

AU - Margaglione, M.

AU - Colaizzo, D.

AU - Iacono, A.

PY - 2001

Y1 - 2001

N2 - We report a case regarding a 71 year-old Caucasian man with NYHA functional class III congestive heart failure, who was under warfarin treatment due to left ventricular thrombosis. After a few days, although the drug was not overdosed, the INR increased up to 11.68. Normal values were reestablished only after a 20-day pharmacological wash-out. Surprisingly, no episode of major or minor bleeding occurred. Gene typing of cytochrome P450 CYP2C9, a liver enzyme responsible for warfarin metabolism, showed that the patient was a carrier of both the mutant alleles (CYP2C9*2/*3) of this enzyme. This genetic defect caused a reduced catabolism of S-warfarin and excessive anticoagulation.

AB - We report a case regarding a 71 year-old Caucasian man with NYHA functional class III congestive heart failure, who was under warfarin treatment due to left ventricular thrombosis. After a few days, although the drug was not overdosed, the INR increased up to 11.68. Normal values were reestablished only after a 20-day pharmacological wash-out. Surprisingly, no episode of major or minor bleeding occurred. Gene typing of cytochrome P450 CYP2C9, a liver enzyme responsible for warfarin metabolism, showed that the patient was a carrier of both the mutant alleles (CYP2C9*2/*3) of this enzyme. This genetic defect caused a reduced catabolism of S-warfarin and excessive anticoagulation.

KW - Anticoagulation

KW - CYP2C9 polymorphism

KW - Warfarin

UR - http://www.scopus.com/inward/record.url?scp=0035008397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035008397&partnerID=8YFLogxK

M3 - Articolo

C2 - 11307788

AN - SCOPUS:0035008397

SN - 1129-4728

VL - 2

SP - 303

EP - 306

JO - Italian Heart Journal Supplement

JF - Italian Heart Journal Supplement

IS - 3

ER -

Ipersensibilità agli anticoagulanti orali: Descrizione di un caso

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this