TY - JOUR
T1 - Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions
AU - Nicot, Christophe
AU - Harrod, Robert L.
AU - Ciminale, Vincenzo
AU - Franchini, Genoveffa
PY - 2005/9/5
Y1 - 2005/9/5
N2 - The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3′ end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.
AB - The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3′ end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.
KW - Genes
KW - HTLV-1
KW - Proteins
KW - Retrovirus
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U2 - 10.1038/sj.onc.1208977
DO - 10.1038/sj.onc.1208977
M3 - Article
C2 - 16155609
AN - SCOPUS:25444436726
SN - 0950-9232
VL - 24
SP - 6026
EP - 6034
JO - Oncogene
JF - Oncogene
IS - 39
ER -