Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Rosanna Mezzapelle; Eltjona Rrapaj; Elena Gatti; Chiara Ceriotti; Francesco De Marchis; Alessandro Preti; Antonello Spinelli; L. Perani; Massimo Venturini; S. Valtorta; R. M. Moresco; Lorenza Pecciarini; Claudio Doglioni; Michela Frenquelli; Luca Crippa; Camilla Recordati; Eugenio Scanziani; Hilda De Vries; Anton Berns; Roberta Frapolli; Renzo Boldorini; Maurizio D'Incalci; Marco E. Bianchi; Massimo Crippa

doi:10.1038/srep22850

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

Rosanna Mezzapelle, Eltjona Rrapaj, Elena Gatti, Chiara Ceriotti, Francesco De Marchis, Alessandro Preti, Antonello Spinelli, L. Perani, Massimo Venturini, S. Valtorta, R. M. Moresco, Lorenza Pecciarini, Claudio Doglioni, Michela Frenquelli, Luca Crippa, Camilla Recordati, Eugenio Scanziani, Hilda De Vries, Anton Berns, Roberta FrapolliRenzo Boldorini, Maurizio D'Incalci, Marco E. Bianchi, Massimo Crippa

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Abstract

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.

Original language	English
Pages (from-to)	22850
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep22850
Publication status	Published - Mar 10 2016

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Mezzapelle, R., Rrapaj, E., Gatti, E., Ceriotti, C., De Marchis, F., Preti, A., Spinelli, A., Perani, L., Venturini, M., Valtorta, S., Moresco, R. M., Pecciarini, L., Doglioni, C., Frenquelli, M., Crippa, L., Recordati, C., Scanziani, E., De Vries, H., Berns, A., ... Crippa, M. (2016). Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells. Scientific Reports, 6, 22850. https://doi.org/10.1038/srep22850

Mezzapelle, R, Rrapaj, E, Gatti, E, Ceriotti, C, De Marchis, F, Preti, A, Spinelli, A, Perani, L, Venturini, M, Valtorta, S, Moresco, RM, Pecciarini, L, Doglioni, C, Frenquelli, M, Crippa, L, Recordati, C, Scanziani, E, De Vries, H, Berns, A, Frapolli, R, Boldorini, R, D'Incalci, M, Bianchi, ME & Crippa, M 2016, 'Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells', Scientific Reports, vol. 6, pp. 22850. https://doi.org/10.1038/srep22850

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title = "Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells",

abstract = "Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.",

author = "Rosanna Mezzapelle and Eltjona Rrapaj and Elena Gatti and Chiara Ceriotti and {De Marchis}, Francesco and Alessandro Preti and Antonello Spinelli and L. Perani and Massimo Venturini and S. Valtorta and Moresco, {R. M.} and Lorenza Pecciarini and Claudio Doglioni and Michela Frenquelli and Luca Crippa and Camilla Recordati and Eugenio Scanziani and {De Vries}, Hilda and Anton Berns and Roberta Frapolli and Renzo Boldorini and Maurizio D'Incalci and Bianchi, {Marco E.} and Massimo Crippa",

year = "2016",

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day = "10",

doi = "10.1038/srep22850",

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T1 - Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

AU - Mezzapelle, Rosanna

AU - Rrapaj, Eltjona

AU - Gatti, Elena

AU - Ceriotti, Chiara

AU - De Marchis, Francesco

AU - Preti, Alessandro

AU - Spinelli, Antonello

AU - Perani, L.

AU - Venturini, Massimo

AU - Valtorta, S.

AU - Moresco, R. M.

AU - Pecciarini, Lorenza

AU - Doglioni, Claudio

AU - Frenquelli, Michela

AU - Crippa, Luca

AU - Recordati, Camilla

AU - Scanziani, Eugenio

AU - De Vries, Hilda

AU - Berns, Anton

AU - Frapolli, Roberta

AU - Boldorini, Renzo

AU - D'Incalci, Maurizio

AU - Bianchi, Marco E.

AU - Crippa, Massimo

PY - 2016/3/10

Y1 - 2016/3/10

N2 - Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.

AB - Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and respond to treatments used for MM patients. Our system largely recapitulates human mesothelioma, and we advocate its use for the study of MM development and treatment.

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Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

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