TY - JOUR
T1 - Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
AU - La Starza, Roberta
AU - Trubia, Maurizio
AU - Crescenzi, Barbara
AU - Matteucci, Caterina
AU - Negrini, Massimo
AU - Martelli, Massimo F.
AU - Pelicci, Pier Giuseppe
AU - Mecucci, Cristina
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.
AB - The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.
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U2 - 10.1002/gcc.10182
DO - 10.1002/gcc.10182
M3 - Article
C2 - 12619167
AN - SCOPUS:0037375919
SN - 1045-2257
VL - 36
SP - 420
EP - 423
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
IS - 4
ER -