Human herpesvirus-7 infection impairs the survival/differentiation of megakaryocytic cells

Arionna Gonelli; Prisco Mirandola; Vittorio Grill; Paola Secchiero; Giorgio Zauli

Human herpesvirus-7 infection impairs the survival/differentiation of megakaryocytic cells

Arionna Gonelli, Prisco Mirandola, Vittorio Grill, Paola Secchiero, Giorgio Zauli

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

In vitro infection of CD61⁺ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.

Original language	English
Pages (from-to)	1223-1225
Number of pages	3
Journal	Haematologica
Volume	87
Issue number	11
Publication status	Published - Nov 1 2002

Keywords

Apoptosis
FACS
Hemotology
Opportunistic infections
Pathogenesis
Virus-cell interaction

ASJC Scopus subject areas

Hematology

Cite this

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title = "Human herpesvirus-7 infection impairs the survival/differentiation of megakaryocytic cells",

abstract = "In vitro infection of CD61+ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.",

keywords = "Apoptosis, FACS, Hemotology, Opportunistic infections, Pathogenesis, Virus-cell interaction",

author = "Arionna Gonelli and Prisco Mirandola and Vittorio Grill and Paola Secchiero and Giorgio Zauli",

year = "2002",

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T1 - Human herpesvirus-7 infection impairs the survival/differentiation of megakaryocytic cells

AU - Gonelli, Arionna

AU - Mirandola, Prisco

AU - Grill, Vittorio

AU - Secchiero, Paola

AU - Zauli, Giorgio

PY - 2002/11/1

Y1 - 2002/11/1

N2 - In vitro infection of CD61+ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.

AB - In vitro infection of CD61+ megakaryocytic cells with human herpesvirus-7 (HHV-7) induced a drastic increase of apoptosis. Moreover, cells surviving HHV-7 cytotoxicity showed enhanced megakaryocytic maturation with respect to control cultures. These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis.

KW - Apoptosis

KW - FACS

KW - Hemotology

KW - Opportunistic infections

KW - Pathogenesis

KW - Virus-cell interaction

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AN - SCOPUS:0036855940

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JO - Haematologica

JF - Haematologica

IS - 11

ER -

Human herpesvirus-7 infection impairs the survival/differentiation of megakaryocytic cells

Abstract

Keywords

ASJC Scopus subject areas

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