TY - JOUR
T1 - Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis
AU - López-Tobón, Alejandro
AU - Villa, Carlo Emanuele
AU - Cheroni, Cristina
AU - Trattaro, Sebastiano
AU - Caporale, Nicolò
AU - Conforti, Paola
AU - Iennaco, Raffaele
AU - Lachgar, Maria
AU - Rigoli, Marco Tullio
AU - Marcó de la Cruz, Berta
AU - Lo Riso, Pietro
AU - Tenderini, Erika
AU - Troglio, Flavia
AU - De Simone, Marco
AU - Liste-Noya, Isabel
AU - Macino, Giuseppe
AU - Pagani, Massimiliano
AU - Cattaneo, Elena
AU - Testa, Giuseppe
PY - 2019/11/12
Y1 - 2019/11/12
N2 - In this article, Testa and colleagues show that the chronic inhibition of GSK3 in human cortical organoids causes early disruption of neural progenitor proliferation and polarity, which turns at later stages into a pronounced defect in neurogenesis and outer radial glia production.
AB - In this article, Testa and colleagues show that the chronic inhibition of GSK3 in human cortical organoids causes early disruption of neural progenitor proliferation and polarity, which turns at later stages into a pronounced defect in neurogenesis and outer radial glia production.
KW - corticogenesis
KW - GSK3
KW - human brain organoids
KW - outer radial glia
KW - single cell transcriptomics
UR - http://www.scopus.com/inward/record.url?scp=85074448325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074448325&partnerID=8YFLogxK
U2 - 10.1016/j.stemcr.2019.09.005
DO - 10.1016/j.stemcr.2019.09.005
M3 - Article
C2 - 31607568
AN - SCOPUS:85074448325
SN - 2213-6711
VL - 13
SP - 847
EP - 861
JO - Stem Cell Reports
JF - Stem Cell Reports
IS - 5
ER -