How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain—A WFUMB Position Paper

F. Prada; I.G. Vetrano; A.G. Gennari; G. Mauri; A. Martegani; L. Solbiati; L.M. Sconfienza; E. Quaia; K.N. Kearns; M.Y.S. Kalani; M.S. Park; F. DiMeco; C. Dietrich

doi:10.1016/j.ultrasmedbio.2021.04.016

How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain—A WFUMB Position Paper

F. Prada, I.G. Vetrano, A.G. Gennari, G. Mauri, A. Martegani, L. Solbiati, L.M. Sconfienza, E. Quaia, K.N. Kearns, M.Y.S. Kalani, M.S. Park, F. DiMeco, C. Dietrich

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Intra-operative ultrasound has become a relevant imaging modality in neurosurgical procedures. While B-mode, with its intrinsic limitations, is still considered the primary ultrasound modality, intra-operative contrast-enhanced ultrasound (ioCEUS) has more recently emerged as a powerful tool in neurosurgery. Though still not used on a large scale, ioCEUS has proven its utility in defining tumor boundaries, identifying lesion vascular supply and mapping neurovascular architecture. Here we propose a step-by-step procedure for performing ioCEUS analysis of the brain, highlighting its neurosurgical applications. Moreover, we provide practical advice on the use of ultrasound contrast agents and review technical ultrasound parameters influencing ioCEUS imaging.

Original language	English
Pages (from-to)	2006-2016
Number of pages	11
Journal	Ultrasound in Medicine and Biology
Volume	47
Issue number	8
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2021.04.016
Publication status	Published - 2021

Keywords

Brain tumors
Central nervous system
CEUS
Contrast-enhanced ultrasound
Intraoperative ultrasounds
Neurosurgery
Neurovascular diseases
Tumors
Central nervous systems
Contrast enhanced ultrasound
Imaging modality
Intra-operative
Intraoperative ultrasound
Neurovascular disease
Position papers
Ultrasound of the brain
Ultrasonics
contrast medium
gadolinium
sulfur hexafluoride
acoustic amplitude
amplitude modulation
analytical error
artifact
blood brain barrier
brain function
brain tissue
clinical practice
computer assisted tomography
contrast enhancement
diagnostic accuracy
diagnostic test accuracy study
dura mater
dynamics
glioma
human
image analysis
image display
image plane signal loss
injection
instrument sterilization
intermethod comparison
intraoperative contrast enhanced ultrasound
intraoperative period
mechanical index
medical history
microbubble
neurosurgery
nuclear magnetic resonance imaging
parameters
postoperative period
practice guideline
preoperative period
pseudo enhancement
pseudo washout
quantitative analysis
reproducibility
Review
safety
surgical technique
time
ultrasound parameters
brain tumor
diagnostic imaging
echography
procedures
Brain Neoplasms
Contrast Media
Humans
Intraoperative Period
Neurosurgical Procedures
Ultrasonography

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10.1016/j.ultrasmedbio.2021.04.016

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107881641&doi=10.1016%2fj.ultrasmedbio.2021.04.016&partnerID=40&md5=d875c3f7eb6ae56ff2b1758016923a36

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Prada, F., Vetrano, I. G., Gennari, A. G., Mauri, G., Martegani, A., Solbiati, L., Sconfienza, L. M., Quaia, E., Kearns, K. N., Kalani, M. Y. S., Park, M. S., DiMeco, F., & Dietrich, C. (2021). How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain—A WFUMB Position Paper. Ultrasound in Medicine and Biology, 47(8), 2006-2016. https://doi.org/10.1016/j.ultrasmedbio.2021.04.016

Prada, F, Vetrano, IG, Gennari, AG, Mauri, G, Martegani, A, Solbiati, L, Sconfienza, LM, Quaia, E, Kearns, KN, Kalani, MYS, Park, MS, DiMeco, F & Dietrich, C 2021, 'How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain—A WFUMB Position Paper', Ultrasound in Medicine and Biology, vol. 47, no. 8, pp. 2006-2016. https://doi.org/10.1016/j.ultrasmedbio.2021.04.016

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abstract = "Intra-operative ultrasound has become a relevant imaging modality in neurosurgical procedures. While B-mode, with its intrinsic limitations, is still considered the primary ultrasound modality, intra-operative contrast-enhanced ultrasound (ioCEUS) has more recently emerged as a powerful tool in neurosurgery. Though still not used on a large scale, ioCEUS has proven its utility in defining tumor boundaries, identifying lesion vascular supply and mapping neurovascular architecture. Here we propose a step-by-step procedure for performing ioCEUS analysis of the brain, highlighting its neurosurgical applications. Moreover, we provide practical advice on the use of ultrasound contrast agents and review technical ultrasound parameters influencing ioCEUS imaging.",

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note = "Export Date: 7 February 2022 CODEN: USMBA Correspondence Address: Prada, F.; Ultrasound NeuroImaging and Therapy Lab, Via G. Celoria 11, Italy; email: francesco.prada@istituto-besta.it",

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AU - Prada, F.

AU - Vetrano, I.G.

AU - Gennari, A.G.

AU - Mauri, G.

AU - Martegani, A.

AU - Solbiati, L.

AU - Sconfienza, L.M.

AU - Quaia, E.

AU - Kearns, K.N.

AU - Kalani, M.Y.S.

AU - Park, M.S.

AU - DiMeco, F.

AU - Dietrich, C.

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KW - echography

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KW - Contrast Media

KW - Humans

KW - Intraoperative Period

KW - Neurosurgical Procedures

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DO - 10.1016/j.ultrasmedbio.2021.04.016

M3 - Article

SN - 0301-5629

VL - 47

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JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

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ER -

How to Perform Intra-Operative Contrast-Enhanced Ultrasound of the Brain—A WFUMB Position Paper

Abstract

Keywords

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