How melanoma cells inactivate NK cells

Gabriella Pietra; Massimo Vitale; Lorenzo Moretta; Maria Cristina Mingari

doi:10.4161/onci.20405

How melanoma cells inactivate NK cells

Gabriella Pietra, Massimo Vitale, Lorenzo Moretta, Maria Cristina Mingari

Research output: Contribution to journal › Article › peer-review

Abstract

NK cells are the most potent effectors against different tumors in vitro. However, their efficacy in vivo is compromised by suppressive signals delivered by tumor or tumor-associated cells. This study unravels the molecular mechanisms by which melanomas disarm NK cells and offers clues to revert such inhibitory effect.

Original language	English
Pages (from-to)	974-975
Number of pages	2
Journal	OncoImmunology
Volume	1
Issue number	6
DOIs	https://doi.org/10.4161/onci.20405
Publication status	Published - 2012

Keywords

IDO
Melanoma cells
NK cells
PGE2
Tumor escape

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.20405

Cite this

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title = "How melanoma cells inactivate NK cells",

abstract = "NK cells are the most potent effectors against different tumors in vitro. However, their efficacy in vivo is compromised by suppressive signals delivered by tumor or tumor-associated cells. This study unravels the molecular mechanisms by which melanomas disarm NK cells and offers clues to revert such inhibitory effect.",

keywords = "IDO, Melanoma cells, NK cells, PGE2, Tumor escape",

author = "Gabriella Pietra and Massimo Vitale and Lorenzo Moretta and Mingari, {Maria Cristina}",

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AU - Vitale, Massimo

AU - Moretta, Lorenzo

AU - Mingari, Maria Cristina

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KW - Melanoma cells

KW - NK cells

KW - PGE2

KW - Tumor escape

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How melanoma cells inactivate NK cells

Abstract

Keywords

ASJC Scopus subject areas

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