How age influences the expression of narcolepsy

Maurice M. Ohayon, Luidgi Ferini-Strambi, Giuseppe Plazzi, Salvatore Smirne, Vincenza Castronovo

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of this study was to investigate the influence of age on the manifestation of narcolepsy symptoms and cognitive difficulties in patients with narcolepsy. Methods: A total of 321 participants were included in the study: 157 were patients with narcolepsy from two Sleep Disorders Clinics and 164 were control participants. Narcoleptic patients were evaluated and diagnosed at the Sleep Disorders Clinic. All participants were interviewed by telephone using the Sleep-EVAL System. The interview comprised, among else, a detailed evaluation of narcolepsy symptoms and of cognitive difficulties. Results: The first manifestation of the disease appeared early in life for most narcoleptic patients: 54.1% had their first symptom before the age of 20 years. Daytime sleepiness was the first symptom to appear in 65.5% of cases. In narcoleptics 60 years or older, cataplexy was more likely to be the first symptom to appear (47.4%) compared with other narcoleptic patients (21.4%; P

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalJournal of Psychosomatic Research
Issue number6
Publication statusPublished - Dec 2005


  • Cataplexy
  • Cognitive functions
  • Narcolepsy
  • Symptom onset

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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