Hormone use and risk for lung cancer: A pooled analysis from the International Lung Cancer Consortium (ILCCO)

A. C. Pesatori; M. Carugno; D. Consonni; R. J. Hung; A. Papadoupolos; M. T. Landi; H. Brenner; H. Müller; C. C. Harris; E. J. Duell; A. S. Andrew; J. R. McLaughlin; A. G. Schwartz; A. S. Wenzlaff; I. Stucker

doi:10.1038/bjc.2013.506

Hormone use and risk for lung cancer: A pooled analysis from the International Lung Cancer Consortium (ILCCO)

A. C. Pesatori, M. Carugno, D. Consonni, R. J. Hung, A. Papadoupolos, M. T. Landi, H. Brenner, H. Müller, C. C. Harris, E. J. Duell, A. S. Andrew, J. R. McLaughlin, A. G. Schwartz, A. S. Wenzlaff, I. Stucker

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Background:The association between oral contraceptive (OC) use, hormone replacement therapy (HRT) and lung cancer risk in women is still debated.Methods:We performed a pooled analysis of six case-control studies (1961 cases and 2609 controls) contributing to the International Lung Cancer Consortium. Potential associations were investigated with multivariable unconditional logistic regression and meta-analytic models. Multinomial logistic regressions were performed to investigate lung cancer risk across histologic types.Results:A reduced lung cancer risk was found for OC (odds ratio (OR)=0.81; 95% confidence interval (CI): 0.68-0.97) and HRT ever users (OR=0.77; 95% CI: 0.66-0.90). Both oestrogen only and oestrogen+progestin HRT were associated with decreased risk (OR=0.76; 95% CI: 0.61-0.94, and OR=0.66; 95% CI: 0.49-0.88, respectively). No dose-response relationship was observed with years of OC/HRT use. The greatest risk reduction was seen for squamous cell carcinoma (OR=0.53; 95% CI: 0.37-0.76) in OC users and in both adenocarcinoma (OR=0.79; 95% CI: 0.66-0.95) and small cell carcinoma (OR=0.37; 95% CI: 0.19-0.71) in HRT users. No interaction with smoking status or BMI was observed.Conclusion:Our findings suggest that exogenous hormones can play a protective role in lung cancer aetiology. However, given inconsistencies with epidemiological evidence from cohort studies, further and larger investigations are needed for a more comprehensive view of lung cancer development in women.

Original language	English
Pages (from-to)	1954-1964
Number of pages	11
Journal	British Journal of Cancer
Volume	109
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2013.506
Publication status	Published - Oct 1 2013

Keywords

exogenous hormones
hormone replacement therapy
lung cancer
oral contraceptives
pooled analysis

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/bjc.2013.506

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Pesatori, A. C., Carugno, M., Consonni, D., Hung, R. J., Papadoupolos, A., Landi, M. T., Brenner, H., Müller, H., Harris, C. C., Duell, E. J., Andrew, A. S., McLaughlin, J. R., Schwartz, A. G., Wenzlaff, A. S., & Stucker, I. (2013). Hormone use and risk for lung cancer: A pooled analysis from the International Lung Cancer Consortium (ILCCO). British Journal of Cancer, 109(7), 1954-1964. https://doi.org/10.1038/bjc.2013.506

Pesatori, AC, Carugno, M, Consonni, D, Hung, RJ, Papadoupolos, A, Landi, MT, Brenner, H, Müller, H, Harris, CC, Duell, EJ, Andrew, AS, McLaughlin, JR, Schwartz, AG, Wenzlaff, AS & Stucker, I 2013, 'Hormone use and risk for lung cancer: A pooled analysis from the International Lung Cancer Consortium (ILCCO)', British Journal of Cancer, vol. 109, no. 7, pp. 1954-1964. https://doi.org/10.1038/bjc.2013.506

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abstract = "Background:The association between oral contraceptive (OC) use, hormone replacement therapy (HRT) and lung cancer risk in women is still debated.Methods:We performed a pooled analysis of six case-control studies (1961 cases and 2609 controls) contributing to the International Lung Cancer Consortium. Potential associations were investigated with multivariable unconditional logistic regression and meta-analytic models. Multinomial logistic regressions were performed to investigate lung cancer risk across histologic types.Results:A reduced lung cancer risk was found for OC (odds ratio (OR)=0.81; 95% confidence interval (CI): 0.68-0.97) and HRT ever users (OR=0.77; 95% CI: 0.66-0.90). Both oestrogen only and oestrogen+progestin HRT were associated with decreased risk (OR=0.76; 95% CI: 0.61-0.94, and OR=0.66; 95% CI: 0.49-0.88, respectively). No dose-response relationship was observed with years of OC/HRT use. The greatest risk reduction was seen for squamous cell carcinoma (OR=0.53; 95% CI: 0.37-0.76) in OC users and in both adenocarcinoma (OR=0.79; 95% CI: 0.66-0.95) and small cell carcinoma (OR=0.37; 95% CI: 0.19-0.71) in HRT users. No interaction with smoking status or BMI was observed.Conclusion:Our findings suggest that exogenous hormones can play a protective role in lung cancer aetiology. However, given inconsistencies with epidemiological evidence from cohort studies, further and larger investigations are needed for a more comprehensive view of lung cancer development in women.",

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AU - Consonni, D.

AU - Hung, R. J.

AU - Papadoupolos, A.

AU - Landi, M. T.

AU - Brenner, H.

AU - Müller, H.

AU - Harris, C. C.

AU - Duell, E. J.

AU - Andrew, A. S.

AU - McLaughlin, J. R.

AU - Schwartz, A. G.

AU - Wenzlaff, A. S.

AU - Stucker, I.

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N2 - Background:The association between oral contraceptive (OC) use, hormone replacement therapy (HRT) and lung cancer risk in women is still debated.Methods:We performed a pooled analysis of six case-control studies (1961 cases and 2609 controls) contributing to the International Lung Cancer Consortium. Potential associations were investigated with multivariable unconditional logistic regression and meta-analytic models. Multinomial logistic regressions were performed to investigate lung cancer risk across histologic types.Results:A reduced lung cancer risk was found for OC (odds ratio (OR)=0.81; 95% confidence interval (CI): 0.68-0.97) and HRT ever users (OR=0.77; 95% CI: 0.66-0.90). Both oestrogen only and oestrogen+progestin HRT were associated with decreased risk (OR=0.76; 95% CI: 0.61-0.94, and OR=0.66; 95% CI: 0.49-0.88, respectively). No dose-response relationship was observed with years of OC/HRT use. The greatest risk reduction was seen for squamous cell carcinoma (OR=0.53; 95% CI: 0.37-0.76) in OC users and in both adenocarcinoma (OR=0.79; 95% CI: 0.66-0.95) and small cell carcinoma (OR=0.37; 95% CI: 0.19-0.71) in HRT users. No interaction with smoking status or BMI was observed.Conclusion:Our findings suggest that exogenous hormones can play a protective role in lung cancer aetiology. However, given inconsistencies with epidemiological evidence from cohort studies, further and larger investigations are needed for a more comprehensive view of lung cancer development in women.

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Hormone use and risk for lung cancer: A pooled analysis from the International Lung Cancer Consortium (ILCCO)

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