Hla typing and affective disorders: A study in the italian population

E. Smeraldi, F. Negri, A. M. Melica, R. Scorza-Smeraldi, G. Fabio, P. Bonara, L. Bellodi, E. Sacchetti, M. G. Sabbadini-Villa, C. L. Cazzullo, C. Zanussi

Research output: Contribution to journalArticlepeer-review


HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
Issue number6
Publication statusPublished - 1978


  • Affective disorders
  • HLA antigens

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)


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