Hla typing and affective disorders: A study in the italian population

E. Smeraldi; F. Negri; A. M. Melica; R. Scorza-Smeraldi; G. Fabio; P. Bonara; L. Bellodi; E. Sacchetti; M. G. Sabbadini-Villa; C. L. Cazzullo; C. Zanussi

doi:10.1159/000117650

Hla typing and affective disorders: A study in the italian population

E. Smeraldi, F. Negri, A. M. Melica, R. Scorza-Smeraldi, G. Fabio, P. Bonara, L. Bellodi, E. Sacchetti, M. G. Sabbadini-Villa, C. L. Cazzullo, C. Zanussi

Research output: Contribution to journal › Article › peer-review

Abstract

HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

Original language	English
Pages (from-to)	344-352
Number of pages	9
Journal	Neuropsychobiology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1159/000117650
Publication status	Published - 1978

Keywords

Affective disorders
HLA antigens

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychology(all)

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10.1159/000117650

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title = "Hla typing and affective disorders: A study in the italian population",

abstract = "HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.",

keywords = "Affective disorders, HLA antigens",

author = "E. Smeraldi and F. Negri and Melica, {A. M.} and R. Scorza-Smeraldi and G. Fabio and P. Bonara and L. Bellodi and E. Sacchetti and Sabbadini-Villa, {M. G.} and Cazzullo, {C. L.} and C. Zanussi",

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doi = "10.1159/000117650",

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T2 - A study in the italian population

AU - Smeraldi, E.

AU - Negri, F.

AU - Melica, A. M.

AU - Scorza-Smeraldi, R.

AU - Fabio, G.

AU - Bonara, P.

AU - Bellodi, L.

AU - Sacchetti, E.

AU - Sabbadini-Villa, M. G.

AU - Cazzullo, C. L.

AU - Zanussi, C.

PY - 1978

Y1 - 1978

N2 - HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

AB - HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

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Hla typing and affective disorders: A study in the italian population

Abstract

Keywords

ASJC Scopus subject areas

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