HLA and multiple sclerosis in Italy: a review of the literature

L. La Mantia; M. T. Illeni; C. Milanese; A. Salmaggi; M. Eoli; G. Pellegris; A. Nespolo

doi:10.1007/BF00314737

HLA and multiple sclerosis in Italy: a review of the literature

L. La Mantia, M. T. Illeni, C. Milanese, A. Salmaggi, M. Eoli, G. Pellegris, A. Nespolo

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

HLA antigens of locus A, C, B, DR and DQ were typed in 104 Italian multiple sclerosis patients and in 905 healthy controls; the results have been compared with those published in the Italian literature. The Italian studies have been reviewed regarding the ethnic origin of the typed population and the corresponding prevalence of the disease. The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease.

Original language	English
Pages (from-to)	441-444
Number of pages	4
Journal	Journal of Neurology
Volume	237
Issue number	7
DOIs	https://doi.org/10.1007/BF00314737
Publication status	Published - Nov 1990

Keywords

HLA
Italy
Multiple sclerosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1007/BF00314737

Cite this

@article{0e79d071dd784437b0b98b0bb7fc65f2,

title = "HLA and multiple sclerosis in Italy: a review of the literature",

abstract = "HLA antigens of locus A, C, B, DR and DQ were typed in 104 Italian multiple sclerosis patients and in 905 healthy controls; the results have been compared with those published in the Italian literature. The Italian studies have been reviewed regarding the ethnic origin of the typed population and the corresponding prevalence of the disease. The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease.",

keywords = "HLA, Italy, Multiple sclerosis",

author = "{La Mantia}, L. and Illeni, {M. T.} and C. Milanese and A. Salmaggi and M. Eoli and G. Pellegris and A. Nespolo",

year = "1990",

month = nov,

doi = "10.1007/BF00314737",

language = "English",

volume = "237",

pages = "441--444",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",

number = "7",

}

TY - JOUR

T1 - HLA and multiple sclerosis in Italy

T2 - a review of the literature

AU - La Mantia, L.

AU - Illeni, M. T.

AU - Milanese, C.

AU - Salmaggi, A.

AU - Eoli, M.

AU - Pellegris, G.

AU - Nespolo, A.

PY - 1990/11

Y1 - 1990/11

N2 - HLA antigens of locus A, C, B, DR and DQ were typed in 104 Italian multiple sclerosis patients and in 905 healthy controls; the results have been compared with those published in the Italian literature. The Italian studies have been reviewed regarding the ethnic origin of the typed population and the corresponding prevalence of the disease. The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease.

AB - HLA antigens of locus A, C, B, DR and DQ were typed in 104 Italian multiple sclerosis patients and in 905 healthy controls; the results have been compared with those published in the Italian literature. The Italian studies have been reviewed regarding the ethnic origin of the typed population and the corresponding prevalence of the disease. The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease.

KW - HLA

KW - Italy

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0025048928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025048928&partnerID=8YFLogxK

U2 - 10.1007/BF00314737

DO - 10.1007/BF00314737

M3 - Article

C2 - 2273414

AN - SCOPUS:0025048928

SN - 0340-5354

VL - 237

SP - 441

EP - 444

JO - Journal of Neurology

JF - Journal of Neurology

IS - 7

ER -

HLA and multiple sclerosis in Italy: a review of the literature

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this