HIV-related pulmonary hypertension. From pathogenesis to clinical aspects

Adriano M. Pellicelli, Cecilia D'Ambrosio, Carmine Dario Vizza, Maria Clotilde Borgia, Piero Tanzi, Paolo Pino, Elisabetta Zachara, Fabrizio Soccorsi

Research output: Contribution to journalArticlepeer-review


HIV-related pulmonary hypertension (HIV-PH) is a cardiovascular complication of HIV infection that has been recognized in the last years with increasing frequency. HIV-related pulmonary hypertension is a clinical disorder which carries a bad prognosis. While a direct HIV infection of the pulmonary vessels in the pathogenesis of this disorder was not demonstrated, currently a multi-factorial pathogenesis of this disease could be hypothesized. Echocardiography has been found to be the most useful screening imaging modality for the diagnosis of HIV-PH, with a high predictive negative value and a low positive predictive value. For this reason Doppler echocardiography is not the gold standard in the diagnosis of HIV-PH. The treatment of HIV-PH is complex and controversial. To date, no study determining the agent of choice for the treatment of this disease exists. Different studies have shown variable results in patiens with HIV-PH treated with highly active antiretroviral therapy (HAART) but only HAART seems not to be effective in lowering pulmonary hypertension in these patients, and in some patients, HIV-PH develops in spite of a previous HAART. It seems reasonable in HIV-PH patients that a treatment with oral vasodilator drugs can improve the adherence of a long-lasting and complex antiretroviral therapy.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalActa Cardiologica
Issue number3
Publication statusPublished - Jun 2004


  • Antiretroviral therapy
  • Cytokines
  • Echocardiography
  • Endothelin-I
  • HIV infection
  • HIV-related pulmonary hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'HIV-related pulmonary hypertension. From pathogenesis to clinical aspects'. Together they form a unique fingerprint.

Cite this