Hippocampal MRI volumetry in cognitively discordant monozygotic twin pairs

T. Järvenpää, M. P. Laakso, R. Rossi, M. Koskenvuo, J. Kaprio, I. Räihä, T. Kurki, M. Laine, G. B. Frisoni, J. O. Rinne

Research output: Contribution to journalArticlepeer-review


Objective: To investigate whether hippocampal atrophy, a proxy for incipient Alzheimer's disease, can be detected in non-demented monozygotic co-twins of demented twins by using volumetric magnetic resonance imaging (MRI). Methods: Seven pairs of monozygotic female twins discordant for cognitive function (mean (SD) age 75 (4) years), and 10 age and education matched healthy controls (seven women, three men; mean age 73 (3) years) were studied with volumetric MRI. Results: The mean normalised right hippocampal volume was 31% lower (p=0.002) in the demented twins, and 6% lower (p=0.45) in the non-demented twins than in the controls. In the left hippocampus, the mean normalised volume was 36% lower (p

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number1
Publication statusPublished - Jan 2004

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health


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