TY - JOUR
T1 - Hippocampal MRI volumetry in cognitively discordant monozygotic twin pairs
AU - Järvenpää, T.
AU - Laakso, M. P.
AU - Rossi, R.
AU - Koskenvuo, M.
AU - Kaprio, J.
AU - Räihä, I.
AU - Kurki, T.
AU - Laine, M.
AU - Frisoni, G. B.
AU - Rinne, J. O.
PY - 2004/1
Y1 - 2004/1
N2 - Objective: To investigate whether hippocampal atrophy, a proxy for incipient Alzheimer's disease, can be detected in non-demented monozygotic co-twins of demented twins by using volumetric magnetic resonance imaging (MRI). Methods: Seven pairs of monozygotic female twins discordant for cognitive function (mean (SD) age 75 (4) years), and 10 age and education matched healthy controls (seven women, three men; mean age 73 (3) years) were studied with volumetric MRI. Results: The mean normalised right hippocampal volume was 31% lower (p=0.002) in the demented twins, and 6% lower (p=0.45) in the non-demented twins than in the controls. In the left hippocampus, the mean normalised volume was 36% lower (p
AB - Objective: To investigate whether hippocampal atrophy, a proxy for incipient Alzheimer's disease, can be detected in non-demented monozygotic co-twins of demented twins by using volumetric magnetic resonance imaging (MRI). Methods: Seven pairs of monozygotic female twins discordant for cognitive function (mean (SD) age 75 (4) years), and 10 age and education matched healthy controls (seven women, three men; mean age 73 (3) years) were studied with volumetric MRI. Results: The mean normalised right hippocampal volume was 31% lower (p=0.002) in the demented twins, and 6% lower (p=0.45) in the non-demented twins than in the controls. In the left hippocampus, the mean normalised volume was 36% lower (p
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M3 - Article
C2 - 14707319
AN - SCOPUS:9144273163
SN - 0022-3050
VL - 75
SP - 116
EP - 120
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 1
ER -