Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives

Luigi Anastasia; Ei ichi Negishi

doi:10.1021/ol010145q

Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives

Luigi Anastasia, Ei ichi Negishi

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

(equation presented) Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.

Original language	English
Pages (from-to)	3111-3113
Number of pages	3
Journal	Organic Letters
Volume	3
Issue number	20
DOIs	https://doi.org/10.1021/ol010145q
Publication status	Published - Oct 4 2001

ASJC Scopus subject areas

Molecular Medicine

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title = "Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives",

abstract = "(equation presented) Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.",

author = "Luigi Anastasia and Negishi, {Ei ichi}",

year = "2001",

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doi = "10.1021/ol010145q",

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T1 - Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives

AU - Anastasia, Luigi

AU - Negishi, Ei ichi

PY - 2001/10/4

Y1 - 2001/10/4

N2 - (equation presented) Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.

AB - (equation presented) Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.

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JO - Organic Letters

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Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives

Abstract

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