TY - JOUR
T1 - High prevalence of low vitamin D and musculoskeletal complaints in women with breast cancer
AU - Napoli, Nicola
AU - Vattikuti, Swapna
AU - Ma, Cynthia
AU - Rastelli, Antonella
AU - Rayani, Anitha
AU - Donepudi, Ravi
AU - Asadfard, Mohammadreza
AU - Yarramaneni, Jayasree
AU - Ellis, Matthew
AU - Armamento-Villareal, Reina
PY - 2010/11
Y1 - 2010/11
N2 - Reduced vitamin D levels may play a significant role in the development of fractures and musculoskeletal pains reported in patients on aromatase inhibitors (AIs) for breast cancer. In this study, we evaluated the vitamin D status in postmenopausal women with non-metastatic breast cancer who were about to start AI therapy. This study was conducted on community dwelling postmenopausal subjects, aged 35-80 years, with early non-metastatic breast cancer (up to stage IIIA), who were about to start therapy using third generation AIs. Symptoms of joint and muscle pains were obtained using a modified Leuven menopausal questionnaire. 25-hydroxyvitamin D [25(OH)D] was evaluated by radioimmunoassay while bone mineral density (BMD) of the lumbar spine and the proximal femur by dual energy x-ray absorptiometry (DXA). Of the 145 participants (mean age = 60.96 ± 0.88 years), 63 of 145 (43.5%) had baseline levels of 25(OH)D of
AB - Reduced vitamin D levels may play a significant role in the development of fractures and musculoskeletal pains reported in patients on aromatase inhibitors (AIs) for breast cancer. In this study, we evaluated the vitamin D status in postmenopausal women with non-metastatic breast cancer who were about to start AI therapy. This study was conducted on community dwelling postmenopausal subjects, aged 35-80 years, with early non-metastatic breast cancer (up to stage IIIA), who were about to start therapy using third generation AIs. Symptoms of joint and muscle pains were obtained using a modified Leuven menopausal questionnaire. 25-hydroxyvitamin D [25(OH)D] was evaluated by radioimmunoassay while bone mineral density (BMD) of the lumbar spine and the proximal femur by dual energy x-ray absorptiometry (DXA). Of the 145 participants (mean age = 60.96 ± 0.88 years), 63 of 145 (43.5%) had baseline levels of 25(OH)D of
KW - aromatase inhibitors
KW - breast cancer
KW - osteoporosis
KW - vitamin D
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U2 - 10.1111/j.1524-4741.2010.01012.x
DO - 10.1111/j.1524-4741.2010.01012.x
M3 - Article
C2 - 21070438
AN - SCOPUS:78449302457
SN - 1075-122X
VL - 16
SP - 609
EP - 616
JO - Breast Journal
JF - Breast Journal
IS - 6
ER -