High prevalence of low vitamin D and musculoskeletal complaints in women with breast cancer

Nicola Napoli, Swapna Vattikuti, Cynthia Ma, Antonella Rastelli, Anitha Rayani, Ravi Donepudi, Mohammadreza Asadfard, Jayasree Yarramaneni, Matthew Ellis, Reina Armamento-Villareal

Research output: Contribution to journalArticlepeer-review


Reduced vitamin D levels may play a significant role in the development of fractures and musculoskeletal pains reported in patients on aromatase inhibitors (AIs) for breast cancer. In this study, we evaluated the vitamin D status in postmenopausal women with non-metastatic breast cancer who were about to start AI therapy. This study was conducted on community dwelling postmenopausal subjects, aged 35-80 years, with early non-metastatic breast cancer (up to stage IIIA), who were about to start therapy using third generation AIs. Symptoms of joint and muscle pains were obtained using a modified Leuven menopausal questionnaire. 25-hydroxyvitamin D [25(OH)D] was evaluated by radioimmunoassay while bone mineral density (BMD) of the lumbar spine and the proximal femur by dual energy x-ray absorptiometry (DXA). Of the 145 participants (mean age = 60.96 ± 0.88 years), 63 of 145 (43.5%) had baseline levels of 25(OH)D of

Original languageEnglish
Pages (from-to)609-616
Number of pages8
JournalBreast Journal
Issue number6
Publication statusPublished - Nov 2010


  • aromatase inhibitors
  • breast cancer
  • osteoporosis
  • vitamin D

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology
  • Surgery


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