High incidence and heterogeneity of functional defects of the alternative pathway of complement among atopic children

A. G. Siccardi; M. M. Marconi; F. A. Ferrari; A. Fortunato; A. Giannetti; F. T. Sacchi; A. Beretta; A. G. Ugazio; S. D. Jayakar

High incidence and heterogeneity of functional defects of the alternative pathway of complement among atopic children

A. G. Siccardi, M. M. Marconi, F. A. Ferrari, A. Fortunato, A. Giannetti, F. T. Sacchi, A. Beretta, A. G. Ugazio, S. D. Jayakar

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Two separate functional defects of the alternate pathway of complement (defective yeast opsonisation and defective rabbit erythrocyte lysis) are very frequent (of the order of 55% for the former and 35% for the latter) among atopic children and their unaffected relatives. The defects are independent of each other and sex, age, season of sampling, type of atopic syndrome and IgE level. The alternative pathway initiation mechanism is probably involved in both defects.

Original language	English
Pages (from-to)	165-170
Number of pages	6
Journal	Journal of Clinical and Laboratory Immunology
Volume	3
Issue number	3
Publication status	Published - 1980

ASJC Scopus subject areas

Immunology

Cite this

@article{f89efaa8e4dd4510ac83f32be08db1d1,

title = "High incidence and heterogeneity of functional defects of the alternative pathway of complement among atopic children",

abstract = "Two separate functional defects of the alternate pathway of complement (defective yeast opsonisation and defective rabbit erythrocyte lysis) are very frequent (of the order of 55% for the former and 35% for the latter) among atopic children and their unaffected relatives. The defects are independent of each other and sex, age, season of sampling, type of atopic syndrome and IgE level. The alternative pathway initiation mechanism is probably involved in both defects.",

author = "Siccardi, {A. G.} and Marconi, {M. M.} and Ferrari, {F. A.} and A. Fortunato and A. Giannetti and Sacchi, {F. T.} and A. Beretta and Ugazio, {A. G.} and Jayakar, {S. D.}",

year = "1980",

language = "English",

volume = "3",

pages = "165--170",

journal = "Journal of Clinical and Laboratory Immunology",

issn = "0141-2760",

publisher = "Teviot Scientific Publications Ltd.",

number = "3",

}

TY - JOUR

T1 - High incidence and heterogeneity of functional defects of the alternative pathway of complement among atopic children

AU - Siccardi, A. G.

AU - Marconi, M. M.

AU - Ferrari, F. A.

AU - Fortunato, A.

AU - Giannetti, A.

AU - Sacchi, F. T.

AU - Beretta, A.

AU - Ugazio, A. G.

AU - Jayakar, S. D.

PY - 1980

Y1 - 1980

N2 - Two separate functional defects of the alternate pathway of complement (defective yeast opsonisation and defective rabbit erythrocyte lysis) are very frequent (of the order of 55% for the former and 35% for the latter) among atopic children and their unaffected relatives. The defects are independent of each other and sex, age, season of sampling, type of atopic syndrome and IgE level. The alternative pathway initiation mechanism is probably involved in both defects.

AB - Two separate functional defects of the alternate pathway of complement (defective yeast opsonisation and defective rabbit erythrocyte lysis) are very frequent (of the order of 55% for the former and 35% for the latter) among atopic children and their unaffected relatives. The defects are independent of each other and sex, age, season of sampling, type of atopic syndrome and IgE level. The alternative pathway initiation mechanism is probably involved in both defects.

UR - http://www.scopus.com/inward/record.url?scp=0018825034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018825034&partnerID=8YFLogxK

M3 - Article

C2 - 7420404

AN - SCOPUS:0018825034

SN - 0141-2760

VL - 3

SP - 165

EP - 170

JO - Journal of Clinical and Laboratory Immunology

JF - Journal of Clinical and Laboratory Immunology

IS - 3

ER -

High incidence and heterogeneity of functional defects of the alternative pathway of complement among atopic children

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this