TY - JOUR
T1 - High GADA titer increases the risk of insulin requirement in LADA patients
T2 - A 7-year follow-up (NIRAD study 7)
AU - Zampetti, Simona
AU - Campagna, Giuseppe
AU - Tiberti, Claudio
AU - Songini, Marco
AU - Arpi, Maria Luisa
AU - De Simone, Giuseppina
AU - Cossu, Efisio
AU - Cocco, Lorenzo
AU - Osborn, John
AU - Bosi, Emanuele
AU - Giorgino, Francesco
AU - Spoletini, Marialuisa
AU - Buzzetti, Raffaella
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective: The aim of this study was to determine whether glutamic acid decarboxylase antibody (GADA) titer and other clinical parameters could define the risk of progression to insulin therapy in latent autoimmune diabetes in adults (LADA) patients during a 7-year follow-up. Methods: This study involved 220 LADA and 430 type 2 diabetes subjects followed up for 7 years from the time of GADA screening to evaluate their progression toward insulin therapy. Kaplan-Meier curves and multivariate logistic regression analysis were performed to identify the markers capable of influencing this progression. Results: During the follow-up, the drop out was 4% in both groups. A total of 119 (56.1%) out of 212 LADA patients required insulin during the 7 years of follow-up. The Kaplan-Meier plots showed that 74/104 (71.1%) of high GADA titer required insulin compared with 45/108 (41.6%) of low GADA titer and with 86/412 (20.9%) of type 2 diabetes ( P2 and IA-2IC and zinc transporter 8 (ZnT8) positivity were also shown as the markers of faster progression (PIC positivity and sulfonylurea treatment, in the first year from diagnosis, significantly increase the progression toward insulin requirement in LADA patients.
AB - Objective: The aim of this study was to determine whether glutamic acid decarboxylase antibody (GADA) titer and other clinical parameters could define the risk of progression to insulin therapy in latent autoimmune diabetes in adults (LADA) patients during a 7-year follow-up. Methods: This study involved 220 LADA and 430 type 2 diabetes subjects followed up for 7 years from the time of GADA screening to evaluate their progression toward insulin therapy. Kaplan-Meier curves and multivariate logistic regression analysis were performed to identify the markers capable of influencing this progression. Results: During the follow-up, the drop out was 4% in both groups. A total of 119 (56.1%) out of 212 LADA patients required insulin during the 7 years of follow-up. The Kaplan-Meier plots showed that 74/104 (71.1%) of high GADA titer required insulin compared with 45/108 (41.6%) of low GADA titer and with 86/412 (20.9%) of type 2 diabetes ( P2 and IA-2IC and zinc transporter 8 (ZnT8) positivity were also shown as the markers of faster progression (PIC positivity and sulfonylurea treatment, in the first year from diagnosis, significantly increase the progression toward insulin requirement in LADA patients.
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U2 - 10.1530/EJE-14-0342
DO - 10.1530/EJE-14-0342
M3 - Article
C2 - 25213702
AN - SCOPUS:84911982531
SN - 0804-4643
VL - 171
SP - 697
EP - 704
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 6
ER -