High frequency of human papillomavirus detection in urinary bladder cancer

Anna Maria Aglianò, Angela Gradilone, Paola Gazzaniga, Maria Napolitano, Roberta Vercillo, Loredana Albonici, Giuseppe Naso, Vittorio Manzari, Luigi Frati, Aldo Vecchione

Research output: Contribution to journalArticlepeer-review


We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV 16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV 16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalUrologia Internationalis
Issue number3
Publication statusPublished - 1994


  • Papillomavirus, Human Carcinoma
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Urology


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