High frequency of human papillomavirus detection in urinary bladder cancer

Anna Maria Aglianò; Angela Gradilone; Paola Gazzaniga; Maria Napolitano; Roberta Vercillo; Loredana Albonici; Giuseppe Naso; Vittorio Manzari; Luigi Frati; Aldo Vecchione

doi:10.1159/000282652

High frequency of human papillomavirus detection in urinary bladder cancer

Anna Maria Aglianò, Angela Gradilone, Paola Gazzaniga, Maria Napolitano, Roberta Vercillo, Loredana Albonici, Giuseppe Naso, Vittorio Manzari, Luigi Frati, Aldo Vecchione

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Abstract

We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV 16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV 16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	Urologia Internationalis
Volume	53
Issue number	3
DOIs	https://doi.org/10.1159/000282652
Publication status	Published - 1994

Keywords

Papillomavirus, Human Carcinoma
Polymerase chain reaction

ASJC Scopus subject areas

Urology

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10.1159/000282652

Cite this

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AU - Aglianò, Anna Maria

AU - Gradilone, Angela

AU - Gazzaniga, Paola

AU - Napolitano, Maria

AU - Vercillo, Roberta

AU - Albonici, Loredana

AU - Naso, Giuseppe

AU - Manzari, Vittorio

AU - Frati, Luigi

AU - Vecchione, Aldo

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AB - We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV 16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV 16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

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High frequency of human papillomavirus detection in urinary bladder cancer

Abstract

Keywords

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