High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients

A. Dufour; A. Salmaggi; L. La Mantia; M. Eoli; A. Nespolo; C. Milanese

doi:10.3109/00207459408986295

High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients

A. Dufour, A. Salmaggi, L. La Mantia, M. Eoli, A. Nespolo, C. Milanese

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3⁺, CD4⁺ and CD4⁺CD45RA⁺ PB lymphocytes and increase in CD3^-CD56⁺ cells. At the end of the treatment, only increase in PB CD19⁺ and in CSF CD8⁺ CD8⁺CD28⁺ and decrease of CSF CD4⁺CD45RA^- and serum IL2R levels were observed. No changes in CD11a⁺CD4⁺, CD18⁺CD4⁺ and CD18⁺CD14⁺ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

Original language	English
Pages (from-to)	119-128
Number of pages	10
Journal	International Journal of Neuroscience
Volume	75
Issue number	1-2
DOIs	https://doi.org/10.3109/00207459408986295
Publication status	Published - 1994

Keywords

HD-MP
IL2R levels
MNCs subsets
MS

ASJC Scopus subject areas

Neuroscience(all)

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10.3109/00207459408986295

Cite this

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title = "High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients",

abstract = "The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+ CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD4+ and CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.",

keywords = "HD-MP, IL2R levels, MNCs subsets, MS",

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AU - Dufour, A.

AU - Salmaggi, A.

AU - Mantia, L. La

AU - Eoli, M.

AU - Nespolo, A.

AU - Milanese, C.

PY - 1994

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N2 - The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+ CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD4+ and CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

AB - The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+ CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD4+ and CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

KW - HD-MP

KW - IL2R levels

KW - MNCs subsets

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High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive ms patients

Abstract

Keywords

ASJC Scopus subject areas

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