High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer

Carlo Barone; Antonio Astone; Carlo Garufi; Antonio Grieco; Antonio Cavallaro; Gaetano Netri; Simonetta Rossi; Alessandra Cassano; Enrico Ricevuto; Maria R. Noviello; Gino Gambassi

doi:10.1016/0277-5379(87)90112-X

High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer

Carlo Barone, Antonio Astone, Carlo Garufi, Antonio Grieco, Antonio Cavallaro, Gaetano Netri, Simonetta Rossi, Alessandra Cassano, Enrico Ricevuto, Maria R. Noviello, Gino Gambassi

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

The therapeutic activity of 5-FU in large bowel cancer is enhanced by increasing the intracellular pool of reduced folates. We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days. None had been given previous radio- or chemotherapy. All had measurable disease. Not one complete response was observed. Thirteen of the 39 evaluable patients showed partial response. Median duration of response was 9+ months. The probability of 50% survival was 15 months for all evaluable patients. There was no case of severe toxicity and the principal toxic effects were oral mucositis and diarrhea. To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer.

Original language	English
Pages (from-to)	1303-1306
Number of pages	4
Journal	European Journal of Cancer and Clinical Oncology
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/0277-5379(87)90112-X
Publication status	Published - 1987

ASJC Scopus subject areas

Oncology

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Barone, C., Astone, A., Garufi, C., Grieco, A., Cavallaro, A., Netri, G., Rossi, S., Cassano, A., Ricevuto, E., Noviello, M. R., & Gambassi, G. (1987). High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer. European Journal of Cancer and Clinical Oncology, 23(9), 1303-1306. https://doi.org/10.1016/0277-5379(87)90112-X

Barone, C, Astone, A, Garufi, C, Grieco, A, Cavallaro, A, Netri, G, Rossi, S, Cassano, A, Ricevuto, E, Noviello, MR & Gambassi, G 1987, 'High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer', European Journal of Cancer and Clinical Oncology, vol. 23, no. 9, pp. 1303-1306. https://doi.org/10.1016/0277-5379(87)90112-X

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title = "High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer",

abstract = "The therapeutic activity of 5-FU in large bowel cancer is enhanced by increasing the intracellular pool of reduced folates. We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days. None had been given previous radio- or chemotherapy. All had measurable disease. Not one complete response was observed. Thirteen of the 39 evaluable patients showed partial response. Median duration of response was 9+ months. The probability of 50% survival was 15 months for all evaluable patients. There was no case of severe toxicity and the principal toxic effects were oral mucositis and diarrhea. To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer.",

author = "Carlo Barone and Antonio Astone and Carlo Garufi and Antonio Grieco and Antonio Cavallaro and Gaetano Netri and Simonetta Rossi and Alessandra Cassano and Enrico Ricevuto and Noviello, {Maria R.} and Gino Gambassi",

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doi = "10.1016/0277-5379(87)90112-X",

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AU - Barone, Carlo

AU - Astone, Antonio

AU - Garufi, Carlo

AU - Grieco, Antonio

AU - Cavallaro, Antonio

AU - Netri, Gaetano

AU - Rossi, Simonetta

AU - Cassano, Alessandra

AU - Ricevuto, Enrico

AU - Noviello, Maria R.

AU - Gambassi, Gino

PY - 1987

Y1 - 1987

N2 - The therapeutic activity of 5-FU in large bowel cancer is enhanced by increasing the intracellular pool of reduced folates. We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days. None had been given previous radio- or chemotherapy. All had measurable disease. Not one complete response was observed. Thirteen of the 39 evaluable patients showed partial response. Median duration of response was 9+ months. The probability of 50% survival was 15 months for all evaluable patients. There was no case of severe toxicity and the principal toxic effects were oral mucositis and diarrhea. To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer.

AB - The therapeutic activity of 5-FU in large bowel cancer is enhanced by increasing the intracellular pool of reduced folates. We treated 45 patients with advanced colon cancer with HDFA and 5-FU for 5 consecutive days. None had been given previous radio- or chemotherapy. All had measurable disease. Not one complete response was observed. Thirteen of the 39 evaluable patients showed partial response. Median duration of response was 9+ months. The probability of 50% survival was 15 months for all evaluable patients. There was no case of severe toxicity and the principal toxic effects were oral mucositis and diarrhea. To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer.

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High-dose folinic acid (HDFA) combined with 5-fluorouracil (5-FU) in first line chemotherapy of advanced large bowel cancer

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