Hepatitis B or C Virus Serology as a Prognostic Factor in Patients with Hepatocellular Carcinoma

Syed A. Ahmad; Malcolm M. Bilimoria; Xuemei Wang; Francesco Izzo; Paolo Delrio; Paolo Marra; Treneth P. Baker; Geoff A. Porter; Lee M. Ellis; Jean N. Vauthey; Sundar Dhamotharan; Steven A. Curley

doi:10.1016/S1091-255X(01)80084-6

Hepatitis B or C Virus Serology as a Prognostic Factor in Patients with Hepatocellular Carcinoma

Syed A. Ahmad, Malcolm M. Bilimoria, Xuemei Wang, Francesco Izzo, Paolo Delrio, Paolo Marra, Treneth P. Baker, Geoff A. Porter, Lee M. Ellis, Jean N. Vauthey, Sundar Dhamotharan, Steven A. Curley

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

It is not clear whether chronic hepatitis B or C virus (HBV or HCV) infection is a prognostic factor for hepatocellular carcinoma. We performed this study to determine if chronic HBV or HCV infection had any impact on postresection survival or affected patterns of failure. The records of 77 patients undergoing surgical resection for hepatocellular carcinoma between January 1990 and December 1998 were reviewed. Forty-four patients (57%) had HCV infection, 18 patients (23%) had HBV infection, and 15 patients (20%) had negative serology. There were no differences in age, sex, or tumor size among the groups, and all patients had margin-negative resections. There was a significantly higher incidence of satellitosis and vascular invasion in patients with HCV infection (32% and 41 %, respectively; P

Original language	English
Pages (from-to)	468-476
Number of pages	9
Journal	Journal of Gastrointestinal Surgery
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/S1091-255X(01)80084-6
Publication status	Published - Sept 2001

Keywords

Hepatitis B
Hepatitis C
Hepatocellular carcinoma
Prognostic factors

ASJC Scopus subject areas

Surgery

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10.1016/S1091-255X(01)80084-6

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Ahmad, S. A., Bilimoria, M. M., Wang, X., Izzo, F., Delrio, P., Marra, P., Baker, T. P., Porter, G. A., Ellis, L. M., Vauthey, J. N., Dhamotharan, S., & Curley, S. A. (2001). Hepatitis B or C Virus Serology as a Prognostic Factor in Patients with Hepatocellular Carcinoma. Journal of Gastrointestinal Surgery, 5(5), 468-476. https://doi.org/10.1016/S1091-255X(01)80084-6

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title = "Hepatitis B or C Virus Serology as a Prognostic Factor in Patients with Hepatocellular Carcinoma",

abstract = "It is not clear whether chronic hepatitis B or C virus (HBV or HCV) infection is a prognostic factor for hepatocellular carcinoma. We performed this study to determine if chronic HBV or HCV infection had any impact on postresection survival or affected patterns of failure. The records of 77 patients undergoing surgical resection for hepatocellular carcinoma between January 1990 and December 1998 were reviewed. Forty-four patients (57%) had HCV infection, 18 patients (23%) had HBV infection, and 15 patients (20%) had negative serology. There were no differences in age, sex, or tumor size among the groups, and all patients had margin-negative resections. There was a significantly higher incidence of satellitosis and vascular invasion in patients with HCV infection (32% and 41 %, respectively; P ",

keywords = "Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Prognostic factors",

author = "Ahmad, {Syed A.} and Bilimoria, {Malcolm M.} and Xuemei Wang and Francesco Izzo and Paolo Delrio and Paolo Marra and Baker, {Treneth P.} and Porter, {Geoff A.} and Ellis, {Lee M.} and Vauthey, {Jean N.} and Sundar Dhamotharan and Curley, {Steven A.}",

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AU - Ahmad, Syed A.

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AU - Izzo, Francesco

AU - Delrio, Paolo

AU - Marra, Paolo

AU - Baker, Treneth P.

AU - Porter, Geoff A.

AU - Ellis, Lee M.

AU - Vauthey, Jean N.

AU - Dhamotharan, Sundar

AU - Curley, Steven A.

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AB - It is not clear whether chronic hepatitis B or C virus (HBV or HCV) infection is a prognostic factor for hepatocellular carcinoma. We performed this study to determine if chronic HBV or HCV infection had any impact on postresection survival or affected patterns of failure. The records of 77 patients undergoing surgical resection for hepatocellular carcinoma between January 1990 and December 1998 were reviewed. Forty-four patients (57%) had HCV infection, 18 patients (23%) had HBV infection, and 15 patients (20%) had negative serology. There were no differences in age, sex, or tumor size among the groups, and all patients had margin-negative resections. There was a significantly higher incidence of satellitosis and vascular invasion in patients with HCV infection (32% and 41 %, respectively; P

KW - Hepatitis B

KW - Hepatitis C

KW - Hepatocellular carcinoma

KW - Prognostic factors

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Hepatitis B or C Virus Serology as a Prognostic Factor in Patients with Hepatocellular Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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