Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor: A care case report

Giuseppe Corrias, Joanna G Escalon, Laura Tang, Serena Monti, Luca Saba, Lorenzo Mannelli

Research output: Contribution to journalArticlepeer-review


RATIONALE: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare.

PATIENT CONCERNS: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness.

DIAGNOSES: The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure. A CT-guided biopsy was performed, revealing a primary mediastinal nonseminomatous germ cell tumor (NSGCT), yolk sac histology, with areas of somatic transformation to malignant nerve sheath tumor. After surgery patient was followed-up with imaging. Two years later a CT scan showed a new hepatic hyper vascular lesion, confirmed by a subsequent magnetic resonance imaging (MRI) and positron emission tomography (PET) scan. A CT-guided biopsy revealed a hepatic metastatic transformation to angiosarcoma of the primitive NSGCT.

INTERVENTIONS: The patient went on to received palliative chemotherapy.

OUTCOMES: The patient is being followed-up regularly at the outpatient department.

LESSONS: Because of the potential of metastatic sarcoma arising from germ cell tumors, these patients should undergo periodical follow-up, with periodical scans. PET\CT scan might have a role in the follow-up of these patients.

Original languageEnglish
Pages (from-to)e9152
Issue number51
Publication statusPublished - Dec 2017


  • Cell Transformation, Neoplastic
  • Diagnostic Imaging
  • Hemangiosarcoma/diagnostic imaging
  • Humans
  • Liver Neoplasms/diagnostic imaging
  • Male
  • Mediastinal Neoplasms/diagnostic imaging
  • Neoplasms, Germ Cell and Embryonal/diagnostic imaging
  • Young Adult


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