Henle Loop Basement Membrane as Initial Site for Randall Plaque Formation

Vincenzo Sepe, Gabriella Adamo, Alfredo La Fianza, Carmelo Libetta, Maria G. Giuliano, Grazia Soccio, Antonio Dal Canton

Research output: Contribution to journalArticlepeer-review


Since the early description of Randall plaques in 1937, studies of the pathogenesis of stone formation mainly focused on the chemistry involving salt precipitation and crystallization, rather than tubular and interstitial medullar mechanisms of calcium concentration and supersaturation. In 2003, Bushinsky published a suggestive and inspiring sequence of events aimed to show that the basement membrane of the thin limb of the loop of Henle can be the first site of nucleation, as recently shown by the impressive work by Evan et al. The aim of this minireview is to verify the consistency of the Evan and Bushinsky theory with the current literature in the field.

Original languageEnglish
Pages (from-to)706-711
Number of pages6
JournalAmerican Journal of Kidney Diseases
Issue number5
Publication statusPublished - Nov 2006


  • hypothesis
  • pathogenesis
  • Urolithiasis

ASJC Scopus subject areas

  • Nephrology


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