In conclusion, There is now sufficient experimental evidence that fibrin and platelets may interact with cancer cells in vitro. The results obtained in vivo with drugs active on hemostasis in various experimental models of dissemination are difficult to interpret in view of the multiplicity of the models and of the range of pharmacological effects of the drugs used. Hemostatic changes certainly occur during development of the Lewis lung carcinoma and the results obtained with anticoagulation and defibrination in this tumor in various experimental conditions suggest that fibrin may well have various roles in different phases of the metastatic spread.
|Number of pages||12|
|Journal||Acta Medica Romana|
|Publication status||Published - 1977|
ASJC Scopus subject areas