Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect

Giovanni Battista Ricci, Diego De Carli, Claudio Colonnese, Giancarlo Di Gennaro, Pier Paolo Quarato, Gianpaolo Cantore, Vincenzo Esposito, Girolamo Garreffa, Bruno Maraviglia

Research output: Contribution to journalArticlepeer-review


We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/fMRI method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas.

Original languageEnglish
Pages (from-to)1487-1492
Number of pages6
JournalMagnetic Resonance Imaging
Issue number10 SPEC. ISS.
Publication statusPublished - Dec 2004


  • Benzodiazepine
  • EEG/fMRI
  • Hemodynamic response

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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