Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect

Giovanni Battista Ricci; Diego De Carli; Claudio Colonnese; Giancarlo Di Gennaro; Pier Paolo Quarato; Gianpaolo Cantore; Vincenzo Esposito; Girolamo Garreffa; Bruno Maraviglia

doi:10.1016/j.mri.2004.10.014

Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect

Giovanni Battista Ricci, Diego De Carli, Claudio Colonnese, Giancarlo Di Gennaro, Pier Paolo Quarato, Gianpaolo Cantore, Vincenzo Esposito, Girolamo Garreffa, Bruno Maraviglia

Research output: Contribution to journal › Article › peer-review

Abstract

We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/fMRI method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas.

Original language	English
Pages (from-to)	1487-1492
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	22
Issue number	10 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mri.2004.10.014
Publication status	Published - Dec 2004

Keywords

Benzodiazepine
BOLD/fMRI
EEG/fMRI
Hemodynamic response

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

Access to Document

10.1016/j.mri.2004.10.014

Cite this

@article{1fdbe48f026543de8988a06dd6e0df95,

title = "Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect",

abstract = "We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images {"}inactivated{"} by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/fMRI method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas.",

keywords = "Benzodiazepine, BOLD/fMRI, EEG/fMRI, Hemodynamic response",

author = "Ricci, {Giovanni Battista} and {De Carli}, Diego and Claudio Colonnese and {Di Gennaro}, Giancarlo and Quarato, {Pier Paolo} and Gianpaolo Cantore and Vincenzo Esposito and Girolamo Garreffa and Bruno Maraviglia",

year = "2004",

month = dec,

doi = "10.1016/j.mri.2004.10.014",

language = "English",

volume = "22",

pages = "1487--1492",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

number = "10 SPEC. ISS.",

}

TY - JOUR

T1 - Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect

AU - Ricci, Giovanni Battista

AU - De Carli, Diego

AU - Colonnese, Claudio

AU - Di Gennaro, Giancarlo

AU - Quarato, Pier Paolo

AU - Cantore, Gianpaolo

AU - Esposito, Vincenzo

AU - Garreffa, Girolamo

AU - Maraviglia, Bruno

PY - 2004/12

Y1 - 2004/12

N2 - We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/fMRI method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas.

AB - We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/fMRI method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas.

KW - Benzodiazepine

KW - BOLD/fMRI

KW - EEG/fMRI

KW - Hemodynamic response

UR - http://www.scopus.com/inward/record.url?scp=13544272771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13544272771&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2004.10.014

DO - 10.1016/j.mri.2004.10.014

M3 - Article

C2 - 15707798

AN - SCOPUS:13544272771

SN - 0730-725X

VL - 22

SP - 1487

EP - 1492

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 10 SPEC. ISS.

ER -

Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this