Heart failure progression in hypertrophic cardiomyopathy - Possible insights from cardiopulmonary exercise testing

Damiano Magrì, Federica Re, Giuseppe Limongelli, Piergiuseppe Agostoni, E. Zachara, Michele Correale, Vittoria Mastromarino, Caterina Santolamazza, Martina Casenghi, Giuseppe Pacileo, Fabio Valente, Marco Morosin, B. Musumeci, Erika Pagannone, Antonello Maruotti, Massimo Uguccioni, Massimo Volpe, Camillo Autore

Research output: Contribution to journalArticlepeer-review


Background: Heart failure (HF) progression and its complications represent major emergent concerns in hypertrophic cardiomyopathy (HCM). We investigated the possible adjunctive role of cardiopulmonary exercise testing (CPET) in predicting HF-related events. An exercise-derived risk model, the HYPertrophic Exercise-derived Risk HF (HYPERHF), has been developed. Methods and Results: A multicenter cohort of 620 consecutive HCM outpatients was recruited and followed (2007 to 2015). The endpoint was death from HF, cardiac transplantation, NYHA III–IV class progression, severe functional deterioration leading to hospitalization for septal reduction, and hospitalization for HF worsening. During a median follow-up of 3.8 years (25–75th centile: 2.3–5.3 years), 84 patients reached the endpoint. Peak circulatory power (peak oxygen consumption * peak systolic blood pressure), ventilatory efficiency and left atrial diameter were independently associated with the endpoint and, accordingly, integrated into the HYPERHF model (C index: 0.849; best cutoff value equal to 15%). Conclusions: CPET is useful in the evaluation of HCM patients. In this context, the HYPERHF score might allow early identification of those patients at high risk of HF progression and its complications.

Original languageEnglish
Pages (from-to)2204-2211
Number of pages8
JournalCirculation Journal
Issue number10
Publication statusPublished - 2016


  • Cardiopulmonary exercise test
  • Heart failure
  • Hypertrophic cardiomyopathy
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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