HBV infection and hepatocellular carcinoma

Massimo Iavarone; Massimo Colombo

doi:10.1016/j.cld.2013.05.002

HBV infection and hepatocellular carcinoma

Massimo Iavarone, Massimo Colombo

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The hepatitis B virus (HBV) plays a dominant role in the 749,000 new cases and 692,000 deaths related to hepatocellular carcinoma (HCC) that are estimated to occur each year worldwide. Chronic infection with HBV is responsible for 60% of HCCs in Asia and Africa and at least 20% of the tumors in Europe, Japan, and the United States. This article discusses the pathogenic role of HBV and the risk of HCC. Tumors almost invariably develop in the context of chronic hepatitis or cirrhosis, which makes early diagnosis the only practical approach to improve prognosis. The treatment options are also discussed.

Original language	English
Pages (from-to)	375-397
Number of pages	23
Journal	Clinics in Liver Disease
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2013.05.002
Publication status	Published - Aug 2013

Keywords

Hepatitis B
Hepatocellular carcinoma
Interferon
Nucleos(t)ide analogues
Surveillance

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2013.05.002

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title = "HBV infection and hepatocellular carcinoma",

abstract = "The hepatitis B virus (HBV) plays a dominant role in the 749,000 new cases and 692,000 deaths related to hepatocellular carcinoma (HCC) that are estimated to occur each year worldwide. Chronic infection with HBV is responsible for 60% of HCCs in Asia and Africa and at least 20% of the tumors in Europe, Japan, and the United States. This article discusses the pathogenic role of HBV and the risk of HCC. Tumors almost invariably develop in the context of chronic hepatitis or cirrhosis, which makes early diagnosis the only practical approach to improve prognosis. The treatment options are also discussed.",

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AU - Colombo, Massimo

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AB - The hepatitis B virus (HBV) plays a dominant role in the 749,000 new cases and 692,000 deaths related to hepatocellular carcinoma (HCC) that are estimated to occur each year worldwide. Chronic infection with HBV is responsible for 60% of HCCs in Asia and Africa and at least 20% of the tumors in Europe, Japan, and the United States. This article discusses the pathogenic role of HBV and the risk of HCC. Tumors almost invariably develop in the context of chronic hepatitis or cirrhosis, which makes early diagnosis the only practical approach to improve prognosis. The treatment options are also discussed.

KW - Hepatitis B

KW - Hepatocellular carcinoma

KW - Interferon

KW - Nucleos(t)ide analogues

KW - Surveillance

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HBV infection and hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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