TY - JOUR
T1 - HBsAg seropositive status and survival after renal transplantation
T2 - Meta-analysis of observational studies
AU - Fabrizi, Fabrizio
AU - Martin, Paul
AU - Dixit, Vivek
AU - Kanwal, Fasiha
AU - Dulai, Gareth
PY - 2005/12
Y1 - 2005/12
N2 - The natural history of hepatitis B virus (HBV) infection after renal transplantation (RT) remains unclear. We conducted a systematic review of the published medical literature on the impact of HBV surface antigen (HBsAg) seropositivity on survival of RT recipients. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the relative risk for mortality and graft loss in HBsAg positive RT recipients across the published studies. We identified six observational studies (6050 unique patients); all of them being cohort, retrospective studies. Pooling of study results demonstrated that HBsAg in serum was an independent and significant risk factor for death after RT; the summary estimate for relative risk was 2.49 with a 95% confidence interval (95% CI) of 1.64-3.78. A test for homogeneity of the relative risk across the studies gave a p-value of
AB - The natural history of hepatitis B virus (HBV) infection after renal transplantation (RT) remains unclear. We conducted a systematic review of the published medical literature on the impact of HBV surface antigen (HBsAg) seropositivity on survival of RT recipients. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the relative risk for mortality and graft loss in HBsAg positive RT recipients across the published studies. We identified six observational studies (6050 unique patients); all of them being cohort, retrospective studies. Pooling of study results demonstrated that HBsAg in serum was an independent and significant risk factor for death after RT; the summary estimate for relative risk was 2.49 with a 95% confidence interval (95% CI) of 1.64-3.78. A test for homogeneity of the relative risk across the studies gave a p-value of
KW - HBV surface antigen (HBsAg)
KW - Hepatitis B virus (HBV)
KW - Meta-analysis
KW - Mortality
KW - Observational studies
KW - Renal transplantation (RT)
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U2 - 10.1111/j.1600-6143.2005.01113.x
DO - 10.1111/j.1600-6143.2005.01113.x
M3 - Article
C2 - 16303005
AN - SCOPUS:33644819694
SN - 1600-6135
VL - 5
SP - 2913
EP - 2921
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 12
ER -