Haemodynamics, exercise capacity and clinical events in pulmonary arterial hypertension

Gianluigi Savarese; Francesca Musella; Carmen D́Amore; Teresa Losco; Caterina Marciano; Paola Gargiulo; Giuseppe Rengo; Santo Dellegrottaglie; Eduardo Bossone; Dario Leosco; Pasquale Perrone-Filardi

doi:10.1183/09031936.00123712

Haemodynamics, exercise capacity and clinical events in pulmonary arterial hypertension

Gianluigi Savarese, Francesca Musella, Carmen D́Amore, Teresa Losco, Caterina Marciano, Paola Gargiulo, Giuseppe Rengo, Santo Dellegrottaglie, Eduardo Bossone, Dario Leosco, Pasquale Perrone-Filardi

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to clarify whether changes in cardiopulmonary haemodynamics induced by pharmacological therapy correlate with exercise capacity and clinical events in patients with pulmonary arterial hypertension. 16 randomised trials including 2353 patients, followed up for 16.4±10.6 weeks, measuring cardiopulmonary haemodynamics by right heart catheterisation and reporting clinical events were included. Meta-analysis and meta-regression analysis were performed to assess the effects of treatments on clinical events and the relationship between haemodynamic changes (pulmonary artery pressure, pulmonary vascular resistance, cardiac index and right atrial pressure) and clinical events. Treatments significantly reduced all-cause death (OR 0.5, 95% CI 0.3́0.7; p

Original language	English
Pages (from-to)	414-424
Number of pages	11
Journal	European Respiratory Journal
Volume	42
Issue number	2
DOIs	https://doi.org/10.1183/09031936.00123712
Publication status	Published - Aug 1 2013

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00123712

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AU - Savarese, Gianluigi

AU - Musella, Francesca

AU - D́Amore, Carmen

AU - Losco, Teresa

AU - Marciano, Caterina

AU - Gargiulo, Paola

AU - Rengo, Giuseppe

AU - Dellegrottaglie, Santo

AU - Bossone, Eduardo

AU - Leosco, Dario

AU - Perrone-Filardi, Pasquale

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Haemodynamics, exercise capacity and clinical events in pulmonary arterial hypertension

Abstract

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