Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey

Adriano Chiò; D. Cocito; M. Leone; M. T. Giordana; G. Mora; R. Mutani; A. Calvo; N. Di Vito; M. Vercellino; A. Bertolotto; E. Bottacchi; L. Mazzini; A. A. Terreni; D. Schiffer; B. Bergamasco; I. Rainero; A. Tribolo; R. Sciolla; F. Mondino; P. Gaviani; F. Monaco; M. De Mattei; E. Morgando; L. Sosso; M. Gionco; U. Morino; M. Nobili; L. Appendino; D. Piazza; E. Oddenino; W. Liboni; G. Vaula; G. Ferrari; M. Favero; C. Doriguzzi Bozzo; P. Santamaria; U. Massazza; E. Bollani; A. Villani; R. Conti; C. Balzarini; M. Palermo; F. Vergnano; S. Cordera; C. Buffa; M. T. Penza; F. Fassio; P. Meineri; A. Cognazzo; C. Mocellini; A. Dutto; A. Cucatto; C. Cavestro; W. Troni; G. Corso

Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey

Adriano Chiò, D. Cocito, M. Leone, M. T. Giordana, G. Mora, R. Mutani, A. Calvo, N. Di Vito, M. Vercellino, A. Bertolotto, E. Bottacchi, L. Mazzini, A. A. Terreni, D. Schiffer, B. Bergamasco, I. Rainero, A. Tribolo, R. Sciolla, F. Mondino, P. GavianiF. Monaco, M. De Mattei, E. Morgando, L. Sosso, M. Gionco, U. Morino, M. Nobili, L. Appendino, D. Piazza, E. Oddenino, W. Liboni, G. Vaula, G. Ferrari, M. Favero, C. Doriguzzi Bozzo, P. Santamaria, U. Massazza, E. Bollani, A. Villani, R. Conti, C. Balzarini, M. Palermo, F. Vergnano, S. Cordera, C. Buffa, M. T. Penza, F. Fassio, P. Meineri, A. Cognazzo, C. Mocellini, A. Dutto, A. Cucatto, C. Cavestro, W. Troni, G. Corso

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

Original language	English
Pages (from-to)	1146-1150
Number of pages	5
Journal	Neurology
Volume	60
Issue number	7
Publication status	Published - Apr 8 2003

ASJC Scopus subject areas

Neuroscience(all)

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Chiò, A., Cocito, D., Leone, M., Giordana, M. T., Mora, G., Mutani, R., Calvo, A., Di Vito, N., Vercellino, M., Bertolotto, A., Bottacchi, E., Mazzini, L., Terreni, A. A., Schiffer, D., Bergamasco, B., Rainero, I., Tribolo, A., Sciolla, R., Mondino, F., ... Corso, G. (2003). Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey. Neurology, 60(7), 1146-1150.

Chiò, A, Cocito, D, Leone, M, Giordana, MT, Mora, G, Mutani, R, Calvo, A, Di Vito, N, Vercellino, M, Bertolotto, A, Bottacchi, E, Mazzini, L, Terreni, AA, Schiffer, D, Bergamasco, B, Rainero, I, Tribolo, A, Sciolla, R, Mondino, F, Gaviani, P, Monaco, F, De Mattei, M, Morgando, E, Sosso, L, Gionco, M, Morino, U, Nobili, M, Appendino, L, Piazza, D, Oddenino, E, Liboni, W, Vaula, G, Ferrari, G, Favero, M, Doriguzzi Bozzo, C, Santamaria, P, Massazza, U, Bollani, E, Villani, A, Conti, R, Balzarini, C, Palermo, M, Vergnano, F, Cordera, S, Buffa, C, Penza, MT, Fassio, F, Meineri, P, Cognazzo, A, Mocellini, C, Dutto, A, Cucatto, A, Cavestro, C, Troni, W & Corso, G 2003, 'Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey', Neurology, vol. 60, no. 7, pp. 1146-1150.

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title = "Guillain-Barr{\'e} syndrome: A prospective, population-based incidence and outcome survey",

abstract = "Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barr{\'e} syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.",

author = "Adriano Chi{\`o} and D. Cocito and M. Leone and Giordana, {M. T.} and G. Mora and R. Mutani and A. Calvo and {Di Vito}, N. and M. Vercellino and A. Bertolotto and E. Bottacchi and L. Mazzini and Terreni, {A. A.} and D. Schiffer and B. Bergamasco and I. Rainero and A. Tribolo and R. Sciolla and F. Mondino and P. Gaviani and F. Monaco and {De Mattei}, M. and E. Morgando and L. Sosso and M. Gionco and U. Morino and M. Nobili and L. Appendino and D. Piazza and E. Oddenino and W. Liboni and G. Vaula and G. Ferrari and M. Favero and {Doriguzzi Bozzo}, C. and P. Santamaria and U. Massazza and E. Bollani and A. Villani and R. Conti and C. Balzarini and M. Palermo and F. Vergnano and S. Cordera and C. Buffa and Penza, {M. T.} and F. Fassio and P. Meineri and A. Cognazzo and C. Mocellini and A. Dutto and A. Cucatto and C. Cavestro and W. Troni and G. Corso",

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pages = "1146--1150",

journal = "Neurology",

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TY - JOUR

T1 - Guillain-Barré syndrome

T2 - A prospective, population-based incidence and outcome survey

AU - Chiò, Adriano

AU - Cocito, D.

AU - Leone, M.

AU - Giordana, M. T.

AU - Mora, G.

AU - Mutani, R.

AU - Calvo, A.

AU - Di Vito, N.

AU - Vercellino, M.

AU - Bertolotto, A.

AU - Bottacchi, E.

AU - Mazzini, L.

AU - Terreni, A. A.

AU - Schiffer, D.

AU - Bergamasco, B.

AU - Rainero, I.

AU - Tribolo, A.

AU - Sciolla, R.

AU - Mondino, F.

AU - Gaviani, P.

AU - Monaco, F.

AU - De Mattei, M.

AU - Morgando, E.

AU - Sosso, L.

AU - Gionco, M.

AU - Morino, U.

AU - Nobili, M.

AU - Appendino, L.

AU - Piazza, D.

AU - Oddenino, E.

AU - Liboni, W.

AU - Vaula, G.

AU - Ferrari, G.

AU - Favero, M.

AU - Doriguzzi Bozzo, C.

AU - Santamaria, P.

AU - Massazza, U.

AU - Bollani, E.

AU - Villani, A.

AU - Conti, R.

AU - Balzarini, C.

AU - Palermo, M.

AU - Vergnano, F.

AU - Cordera, S.

AU - Buffa, C.

AU - Penza, M. T.

AU - Fassio, F.

AU - Meineri, P.

AU - Cognazzo, A.

AU - Mocellini, C.

AU - Dutto, A.

AU - Cucatto, A.

AU - Cavestro, C.

AU - Troni, W.

AU - Corso, G.

PY - 2003/4/8

Y1 - 2003/4/8

N2 - Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

AB - Objective: The authors evaluated the incidence and long-term prognostic factors of Guillain-Barré syndrome (GBS) in a prospective, population-based study. Methods: Patients with GBS diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke criteria in the 2-year period 1995 to 1996 in two Italian regions were prospectively followed up for 2 years after onset of GBS. Results: A total of 120 patients were found, corresponding to a crude annual incidence rate of 1.36/100,000 population (95% CI, 1.13 to 1.63). A total of 7 (5.8%) patients, all but one with axonal or mixed EMG pattern, died acutely within 30 days from the onset of the disease. Acute mortality was due to respiratory involvement and intensive care unit complications. In multivariate analysis, a worse 2-year outcome (Hughes score ≥ 2) was related to a higher Hughes grade at nadir, axonal or mixed EMG, age ≥ 50 years, and absence of respiratory infections preceding GBS. The persistence of disability 2 years after the acute phase was related to axonal involvement and a worse status at nadir. Conclusions: After adjustment to US population, the incidence rates for GBS from different countries showed no significant differences. Both acute mortality and long-term disability in GBS seem to be related to an axonal involvement and a Hughes grade ≥ 2 at nadir.

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ER -

Guillain-Barré syndrome: A prospective, population-based incidence and outcome survey

Abstract

ASJC Scopus subject areas

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