Growth hormone response to growth hormone-releasing hormone stimulation in obsessive-compulsive disorder

Francesca Brambilla; Laura Bellodi; Giampaolo Perna; Cinzia Arancio; Angelo Bertani

doi:10.1016/S0165-1781(98)00124-3

Growth hormone response to growth hormone-releasing hormone stimulation in obsessive-compulsive disorder

Francesca Brambilla, Laura Bellodi, Giampaolo Perna, Cinzia Arancio, Angelo Bertani

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone- releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.

Original language	English
Pages (from-to)	293-299
Number of pages	7
Journal	Psychiatry Research
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/S0165-1781(98)00124-3
Publication status	Published - Dec 14 1998

Keywords

Endocrine factors
Obsessive compulsive disorder
Somatomedin-C
Somatotropic axis

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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10.1016/S0165-1781(98)00124-3

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title = "Growth hormone response to growth hormone-releasing hormone stimulation in obsessive-compulsive disorder",

abstract = "Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone- releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.",

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AU - Perna, Giampaolo

AU - Arancio, Cinzia

AU - Bertani, Angelo

PY - 1998/12/14

Y1 - 1998/12/14

N2 - Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone- releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.

AB - Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone- releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.

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Growth hormone response to growth hormone-releasing hormone stimulation in obsessive-compulsive disorder

Abstract

Keywords

ASJC Scopus subject areas

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