Growth and pubertal disorders in neurofibromatosis type 1

R. Virdis, M. E. Street, M. A. Bandello, C. Tripodi, A. Donadio, A. R. Villani, L. Cagozzi, L. Garaveli, S. Bernasconi

Research output: Contribution to journalArticlepeer-review


The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Issue numberSUPPL. 2
Publication statusPublished - 2003


  • Delayed puberty
  • GnRH agonist therapy
  • Growth
  • Neurofibromatosis type 1
  • Optic gliomas
  • Optic pathway tumors
  • Precocious puberty

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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