Growth and pubertal disorders in neurofibromatosis type 1

R. Virdis; M. E. Street; M. A. Bandello; C. Tripodi; A. Donadio; A. R. Villani; L. Cagozzi; L. Garaveli; S. Bernasconi

Growth and pubertal disorders in neurofibromatosis type 1

R. Virdis, M. E. Street, M. A. Bandello, C. Tripodi, A. Donadio, A. R. Villani, L. Cagozzi, L. Garaveli, S. Bernasconi

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	16
Issue number	SUPPL. 2
Publication status	Published - 2003

Keywords

Delayed puberty
GnRH agonist therapy
Growth
Neurofibromatosis type 1
Optic gliomas
Optic pathway tumors
Precocious puberty

ASJC Scopus subject areas

Endocrinology
Pediatrics, Perinatology, and Child Health

Cite this

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title = "Growth and pubertal disorders in neurofibromatosis type 1",

abstract = "The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p ",

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AU - Virdis, R.

AU - Street, M. E.

AU - Bandello, M. A.

AU - Tripodi, C.

AU - Donadio, A.

AU - Villani, A. R.

AU - Cagozzi, L.

AU - Garaveli, L.

AU - Bernasconi, S.

PY - 2003

Y1 - 2003

N2 - The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p

AB - The first textbook of Pediatric Endocrinology in the early 1950s reported an association of neurofibromatosis type 1 (NF1) and precocious puberty (PP) and/or short stature. Recent studies have indicated that children with NF1 grow normally until puberty; thereafter height velocity and relative height (SDS or percentiles) decreases with respect to healthy peers, reaching a mean adult height close to the 25th percentile for the general population. Moreover, the percentage of patients with true short stature (2 SD): 16% vs 6.8% (mothers) vs 3.4% (controls) (p

KW - Delayed puberty

KW - GnRH agonist therapy

KW - Growth

KW - Neurofibromatosis type 1

KW - Optic gliomas

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Growth and pubertal disorders in neurofibromatosis type 1

Abstract

Keywords

ASJC Scopus subject areas

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